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利奈唑胺治疗播散性单核细胞增生李斯特菌脑膜炎和中枢神经系统脓肿的活性:关注早期药物骨髓毒性。

Linezolid activity against disseminated Listeria monocytogenes meningitis and central nervous system abscesses: focus on early drug myelotoxicity.

作者信息

Manfredi Roberto

机构信息

Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

出版信息

Curr Drug Saf. 2007 May;2(2):141-5. doi: 10.2174/157488607780598304.

DOI:10.2174/157488607780598304
PMID:18690960
Abstract

A very infrequent report of Listeria monocytogenes meningitis and multiple subtentorial abscesses (cerebellar, bulbar, and pontine in location), occurred in an immunocompetent man, and is described and discussed on the ground of the most recent literature evidences regarding the frequency, presentation, and outcome of this disease. The possibility to resort to combination linezolid therapy in patients who appear to be not responsive to first-line treatment of cerebral abscess of definite origin, and the appearance of anemia as an early untoward event of this novel oxazolidinone antibiotic, are also debated.

摘要

一名免疫功能正常的男性发生了非常罕见的单核细胞增生李斯特菌脑膜炎及多个幕下脓肿(位于小脑、延髓和脑桥),本文根据关于该疾病的发病率、临床表现及转归的最新文献证据对其进行描述和讨论。对于明确病因的脑脓肿一线治疗无反应的患者采用利奈唑胺联合治疗的可能性,以及作为这种新型恶唑烷酮类抗生素早期不良事件的贫血的出现,也进行了讨论。

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