Bishop Thomas, Ballard Angela, Holmes Helen, Young Antony R, McMahon Stephen B
Neurorestoration Group, The Wolfson Centre for Age Related Disease, King's College London, The Wolfson Wing, Hodgkin Building, Guy's Campus, London Bridge, London SE11UL, United Kingdom.
Eur J Pain. 2009 May;13(5):524-32. doi: 10.1016/j.ejpain.2008.06.006. Epub 2008 Aug 8.
The effect on human skin of over-exposure to solar ultraviolet radiation (UVR) has been well described. The erythema produced is commonly referred to as 'sunburn'. Recently UVR induced inflammation has been utilised as a human model of sub-acute pain. Our aim was to characterise the sensory phenotype of UVB inflammation in human volunteers. We delivered UVB to small areas of volar forearm skin in healthy volunteers and found that the degree of inflammation and concomitant increase in sensitivity to cutaneous stimuli were UVB dose and time dependent. We directly compared UVB induced inflammation and the more established thermal burn and topical capsaicin pain models. UVB inflammation produced precisely demarcated erythematous lesions without secondary flare. Both thermal burns and topical capsaicin produced large areas of flare, indistinguishable in character from the primary lesions. Moreover, UVB inflammation induced large reductions in mechanical pain threshold restricted to the primary lesion site, whereas the more established inflammatory pain models produced not only primary hypersensitivity but also significant areas of secondary mechanical hypersensitivity. Taken together these findings suggest that UVB inflammation, at least using moderate doses produces sensory changes primarily by sensitising peripheral pain processing in the relative absence of alterations in central pain processing.
过度暴露于太阳紫外线辐射（UVR）对人体皮肤的影响已有详尽描述。产生的红斑通常被称为“晒伤”。近来，UVR诱导的炎症已被用作亚急性疼痛的人体模型。我们的目的是描绘人类志愿者中UVB炎症的感觉表型。我们对健康志愿者掌侧前臂皮肤的小面积区域给予UVB，发现炎症程度以及对皮肤刺激敏感性的相应增加与UVB剂量和时间相关。我们直接比较了UVB诱导的炎症与更成熟的热烧伤和局部辣椒素疼痛模型。UVB炎症产生界限分明的红斑性病变，无继发性潮红。热烧伤和局部辣椒素都产生大面积的潮红，其特征与原发性病变难以区分。此外，UVB炎症导致机械性疼痛阈值大幅降低，且局限于原发性病变部位，而更成熟的炎性疼痛模型不仅产生原发性超敏反应，还产生显著的继发性机械性超敏反应区域。综合这些发现表明，至少使用中等剂量时，UVB炎症主要通过在相对未改变中枢性疼痛处理的情况下使外周疼痛处理敏感化来产生感觉变化。
