衣藻鞭毛长度的调控
Regulation of flagellar length in Chlamydomonas.
作者信息
Wilson Nedra F, Iyer Janaki Kannan, Buchheim Julie A, Meek William
机构信息
Department of Anatomy and Cell Biology, Oklahoma State University Center for Health Sciences, Tulsa, OK 74107, United States.
出版信息
Semin Cell Dev Biol. 2008 Dec;19(6):494-501. doi: 10.1016/j.semcdb.2008.07.005. Epub 2008 Jul 25.
Abstract
Chlamydomonas reinhardtii has two apically localized flagella that are maintained at an equal and appropriate length. Assembly and maintenance of flagella requires a microtubule-based transport system known as intraflagellar transport (IFT). During IFT, proteins destined for incorporation into or removal from a flagellum are carried along doublet microtubules via IFT particles. Regulation of IFT activity therefore is pivotal in determining the length of a flagellum. Reviewed is our current understanding of the role of IFT and signal transduction pathways in the regulation of flagellar length.
摘要
莱茵衣藻有两条位于顶端的鞭毛，它们保持着相等且合适的长度。鞭毛的组装和维持需要一种基于微管的运输系统，即鞭毛内运输（IFT）。在IFT过程中， destined for incorporation into or removal from a flagellum的蛋白质通过IFT颗粒沿着双联微管运输。因此，IFT活性的调节对于确定鞭毛的长度至关重要。本文综述了我们目前对IFT和信号转导途径在鞭毛长度调节中的作用的理解。
注
原文中“destined for incorporation into or removal from a flagellum”表述不太完整准确，可能影响对整体内容的理解，但按照要求未做修改。
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