Wu Xunwei, Liang Yihuai, Jin Taiyi, Ye Tingting, Kong Qinghu, Wang Zaijuan, Lei Lijian, Bergdahl Ingvar A, Nordberg Gunnar F
Department of Occupational Health, School of Public Health, Fudan University, Shanghai 200032, PR China.
Environ Res. 2008 Oct;108(2):233-8. doi: 10.1016/j.envres.2008.02.011. Epub 2008 Aug 8.
Cadmium is a well-known nephrotoxic agent with extremely long biological half-time of 10-30 years in human. To investigate the evolution of cadmium-induced renal effects in the population, a number of 148 residents who lived in cadmium-polluted area were followed-up for 3 years after the reduction of cadmium exposure in rice. Urinary cadmium (UCd), beta(2)-microglobulin (B2M) and albumin (ALB) were analyzed in 1995 and 1998, respectively. The results demonstrated that the changes of renal effects of residents depended on the levels of UCd before inflow of cadmium to human body declined. In cases where UCd were less than 10 microg/g creatinine in 1995, evidence was found indicating significant decreases in proteinuria (i.e., B2M and ALB) 3 years later, whereas, in cases where the excretion of UCd exceeded 10 microg/g creatinine in 1995, progression was observed. The study of dose-response relationships between UCd and B2M or ALB also showed that the cadmium-induced renal dysfunction might be reversible if UCd concentration was low-level before exposure decreasing, otherwise it might be irreversible or aggravated.
镉是一种著名的肾毒性物质，在人体中的生物半衰期极长，为10至30年。为了研究人群中镉诱导的肾脏效应的演变，对148名居住在镉污染地区的居民在大米中镉暴露减少后进行了3年的随访。分别于1995年和1998年分析了尿镉（UCd）、β2-微球蛋白（B2M）和白蛋白（ALB）。结果表明，居民肾脏效应的变化取决于镉进入人体前UCd的水平。在1995年UCd低于10微克/克肌酐的情况下，发现有证据表明3年后蛋白尿（即B2M和ALB）显著减少，而在1995年UCd排泄量超过10微克/克肌酐的情况下，则观察到病情进展。对UCd与B2M或ALB之间剂量反应关系的研究还表明，如果暴露减少前UCd浓度处于低水平，镉诱导的肾功能障碍可能是可逆的，否则可能是不可逆的或会加重。
