Le Floch Vincent, Luo Gangming, Kaufman Jonathan J, Siffert Robert S
Ecole Nationale Superieure d'Arts et Metiers, Aix-en-Provence, Provence-Alpes-Cote-d'Azur, France.
Ultrasound Med Biol. 2008 Dec;34(12):1972-9. doi: 10.1016/j.ultrasmedbio.2008.05.010. Epub 2008 Aug 9.
The overall objective of this research is to develop an ultrasonic system for noninvasive assessment of the distal radius. The specific objective of this study was to examine the relationship between geometrical features of cortical bone and ultrasound measurements in vitro. Nineteen radii were measured in through transmission in a water bath. A 3.5 MHz rectangular (1 cm x 4.8 cm) single element transducer served as the source and a 3.5 MHz rectangular (1 cm x 4.8 cm) linear array transducer served as the receiver. The linear array consisted of 64 elements with a pitch of 0.75 mm. Ultrasound measurements were carried out at a location that was 1/3rdrd of the length from the distal end of each radius and two net time delay parameters, tau(NetDW) and tau(NetCW), associated with a direct wave (DW) and a circumferential wave (CW), respectively, were evaluated. The cortical thickness (CT), medullar thickness (MT) and cross-sectional area (CSA) of each radius was also evaluated based on a digital image of the cross-section at the 1/3rd location. The linear correlations between CT and tau(NetDW) was r = 0.91 (p < 0.001) and between MT and tau(NetCW) - tau(NetDW) was r = 0.63 (p < 0.05). The linear correlation between CSA and a nonlinear combination of the two net time delays, tau(NetDW) and tau(NetCW), was r = 0.95 (p < 0.001). The study shows that ultrasound measurements can be used to noninvasively assess cortical bone geometrical features in vitro as represented by cortical thickness, medullar thickness and cross-sectional area.
本研究的总体目标是开发一种用于无创评估桡骨远端的超声系统。本研究的具体目标是在体外研究皮质骨几何特征与超声测量之间的关系。在水浴中通过透射对19根桡骨进行测量。一个3.5兆赫兹的矩形（1厘米×4.8厘米）单元素换能器作为声源，一个3.5兆赫兹的矩形（1厘米×4.8厘米）线性阵列换能器作为接收器。线性阵列由64个元件组成，间距为0.75毫米。在距每根桡骨远端长度的1/3处进行超声测量，并分别评估与直达波（DW）和圆周波（CW）相关的两个净时延参数tau(NetDW)和tau(NetCW)。还基于在1/3位置处的横截面数字图像评估每根桡骨的皮质厚度（CT）、髓腔厚度（MT）和横截面积（CSA）。CT与tau(NetDW)之间的线性相关系数r = 0.91（p < 0.001），MT与tau(NetCW) - tau(NetDW)之间的线性相关系数r = 0.63（p < 0.05）。CSA与两个净时延tau(NetDW)和tau(NetCW)的非线性组合之间的线性相关系数r = 0.95（p < 0.001）。该研究表明，超声测量可用于在体外无创评估以皮质厚度、髓腔厚度和横截面积表示的皮质骨几何特征。
