Kaya Cemil, Cengiz Sevim Dinçer, Berker Bülent, Demirtaş Selda, Cesur Mustafa, Erdoğan Gürbüz
Department of Obstetrics and Gynecology, Ufuk University, Ankara, Turkey.
Fertil Steril. 2009 Aug;92(2):635-42. doi: 10.1016/j.fertnstert.2008.06.006. Epub 2008 Aug 9.
To test the hypothesis that statins improve hyperhomocysteinemia in women with polycystic ovary syndrome (PCOS).
A prospective randomized study.
University Hospital.
PATIENT(S): Fifty-two women with PCOS and 52 women matched for age and body mass index as controls.
INTERVENTION(S): Patients were randomly divided into two groups for treatment: group 1, atorvastatin, 20 mg daily (n = 26), and group 2, simvastatin, 20 mg daily (n = 26). Blood samples were obtained before and after treatment.
MAIN OUTCOME MEASURE(S): Serum homocysteine levels.
RESULT(S): After 12 weeks of treatment, serum homocysteine levels in group 1 had decreased from 14.3 +/- 2.9 to 10.6 +/- 1.7 micromol/L; in group 2, the levels decreased from 13.6 +/- 2.1 to 11.1 +/- 1.9 micromol/L. Both two groups, free testosterone and total testosterone declined statistically significantly (38.3% and 36.5%; and 40.6% and 46.0%, respectively). In group 1, vitamin B(12) increased from 362.1 +/- 107 to 478.7 +/- 267 pg/mL; in group 2, it increased from 391.3 +/- 107 to 466 +/- 211 pg/mL, but the change did not reach statistical significance. There was a considerable decline in the homeostatic model assessment index in group 1 (40.0% to 32.1%).
CONCLUSION(S): Treatment with statins in women with PCOS leads to decreases in serum homocysteine levels.
检验他汀类药物可改善多囊卵巢综合征（PCOS）女性高同型半胱氨酸血症这一假设。
一项前瞻性随机研究。
大学医院。
52例PCOS女性以及52例年龄和体重指数相匹配的女性作为对照。
患者被随机分为两组进行治疗：第1组，阿托伐他汀，每日20毫克（n = 26）；第2组，辛伐他汀，每日20毫克（n = 26）。治疗前后采集血样。
血清同型半胱氨酸水平。
治疗12周后，第1组血清同型半胱氨酸水平从14.3±2.9降至10.6±1.7微摩尔/升；第2组，该水平从13.6±2.1降至11.1±1.9微摩尔/升。两组的游离睾酮和总睾酮均有统计学显著下降（分别为38.3%和36.5%；以及40.6%和46.0%）。第1组中，维生素B12从362.1±107升至478.7±267皮克/毫升；第2组中，其从391.3±107升至466±211皮克/毫升，但变化未达到统计学显著水平。第1组的稳态模型评估指数有相当程度下降（从40.0%降至32.1%）。
PCOS女性使用他汀类药物治疗可导致血清同型半胱氨酸水平降低。
