Kelishadi Roya, Mirghaffari Nourollah, Poursafa Parinaz, Gidding Samuel S
Isfahan Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Atherosclerosis. 2009 Mar;203(1):311-9. doi: 10.1016/j.atherosclerosis.2008.06.022. Epub 2008 Jul 1.
Reaching a better understanding of the modifiable factors associated with inflammatory and oxidative biomarkers in children would be relevant to the design of further investigation and prevention strategies.
To determine the association of air pollution as well as dietary and physical activity habits with markers of inflammation, oxidative stress and insulin resistance for the first time in a population-based sample of children.
We conducted a population-based study of 374 children, aged 10-18 years, and assessed the exposure of participants to air pollutants as well as their dietary and physical activity habits. In addition to anthropometric and blood pressure measurements, we determined the fasting serum levels of lipid profile, insulin and markers of inflammation and oxidation.
We found independent associations between improper air quality and plasma markers of inflammation, oxidative stress and insulin resistance. The Pollutant Standard Index (PSI) and the level of fine particulate matter were significantly associated to all biomarkers studied. The associations between different markers of air pollutants and markers of inflammation, oxidative stress and insulin resistance remained significant after adjustment for age, gender, body mass index, waist circumference, healthy eating index and physical activity level. The association of healthy eating score with CRP and insulin resistance was mediated through anthropometric indices, and physical activity had independent association with insulin resistance.
The independent influence of inflammatory/oxidative mechanisms of air pollution effects on surrogate markers of atherosclerosis from early life should be highlighted.
更好地了解与儿童炎症和氧化生物标志物相关的可改变因素，将有助于进一步研究和预防策略的设计。
首次在基于人群的儿童样本中，确定空气污染以及饮食和身体活动习惯与炎症、氧化应激和胰岛素抵抗标志物之间的关联。
我们对374名10至18岁的儿童进行了一项基于人群的研究，评估了参与者接触空气污染物的情况以及他们的饮食和身体活动习惯。除了进行人体测量和血压测量外，我们还测定了空腹血清中的血脂水平、胰岛素以及炎症和氧化标志物。
我们发现空气质量不佳与炎症、氧化应激和胰岛素抵抗的血浆标志物之间存在独立关联。污染物标准指数（PSI）和细颗粒物水平与所有研究的生物标志物均显著相关。在对年龄、性别、体重指数、腰围、健康饮食指数和身体活动水平进行调整后，空气污染物的不同标志物与炎症、氧化应激和胰岛素抵抗标志物之间的关联仍然显著。健康饮食评分与CRP和胰岛素抵抗的关联是通过人体测量指标介导的，而身体活动与胰岛素抵抗有独立关联。
应强调空气污染影响的炎症/氧化机制对早期动脉粥样硬化替代标志物的独立影响。
