Nutrition Innovation Center, Standard Process Inc., 150 N Research Campus Dr, Kannapolis, NC 28081, USA.
Plants for Human Health Institute, NC State University, 600 Laureate Way, Kannapolis, NC 28081, USA.
Nutrients. 2023 May 6;15(9):2209. doi: 10.3390/nu15092209.
Adequate antioxidant supply is essential for maintaining metabolic homeostasis and reducing oxidative stress during detoxification. The emerging evidence suggests that certain classes of phytonutrients can help support the detoxification process by stimulating the liver to produce detoxification enzymes or acting as antioxidants that neutralize the harmful effects of free radicals. This study was designed to examine the effects of a guided 28-day metabolic detoxification program in healthy adults. The participants were randomly assigned to consume a whole food, multi-ingredient supplement ( = 14, education and intervention) or control ( = 18, education and healthy meal) daily for the duration of the trial. The whole food supplement contained 37 g/serving of a proprietary, multicomponent nutritional blend in the form of a rehydratable shake. Program readiness was ensured at baseline using a validated self-perceived wellness score and a blood metabolic panel, indicating stable emotional and physical well-being in both groups. No significant changes or adverse effects were found on physical or emotional health, cellular glutathione (GSH) and the GSH:GSSG ratio, porphyrin, and hepatic detoxification biomarkers in urine. The intervention was positively associated with a 23% increase in superoxide dismutase ( = 0.06) and a 13% increase in glutathione S-transferase ( = 0.003) activities in the blood. This resulted in a 40% increase in the total cellular antioxidant capacity ( = 0.001) and a 13% decrease in reactive oxygen species ( = 0.002) in isolated PBMCs from participants in the detoxification group. Our findings indicate that consuming a whole food nutritional intervention as a part of the guided detoxification program supported phase II detoxification, in part, by promoting enhanced free radical scavenging and maintaining redox homeostasis under the body's natural glutathione recycling capacity.
足够的抗氧化剂供应对于维持新陈代谢的平衡和减少解毒过程中的氧化应激是至关重要的。新出现的证据表明，某些类别的植物营养素可以通过刺激肝脏产生解毒酶或作为抗氧化剂来中和自由基的有害影响，从而帮助支持解毒过程。本研究旨在检验一种为期 28 天的代谢解毒计划对健康成年人的影响。参与者被随机分配每天食用一种全食物、多成分补充剂（= 14 名，教育和干预）或对照（= 18 名，教育和健康餐），持续整个试验过程。全食物补充剂每份含有 37 克专利多成分营养混合物，形式为可再水化的奶昔。在基线时使用经过验证的自我感知健康评分和血液代谢小组来确保计划准备就绪，这表明两组的情绪和身体都处于稳定的健康状态。在身体或情绪健康、细胞谷胱甘肽（GSH）和 GSH：GSSG 比值、卟啉和尿液中的肝脏解毒生物标志物方面，没有发现显著变化或不良影响。干预与血液中超氧化物歧化酶活性增加 23%（= 0.06）和谷胱甘肽 S-转移酶活性增加 13%（= 0.003）呈正相关。这导致解毒组参与者的总细胞抗氧化能力增加 40%（= 0.001），活性氧减少 13%（= 0.002）。我们的研究结果表明，作为指导解毒计划的一部分，食用全食物营养干预有助于支持第二阶段的解毒，部分原因是通过促进增强自由基清除和维持体内天然谷胱甘肽循环能力下的氧化还原平衡。
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