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伴有肺部受累的坏疽性脓皮病?

Pyoderma gangrenosum with pulmonary involvement?

作者信息

Liu Ze-Hu, Lu Xue-Lian, Fu Mei-Hua, Zhang Guo-Yi, Liu Wei-Da

机构信息

Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, China.

出版信息

Eur J Dermatol. 2008 Sep-Oct;18(5):583-5. doi: 10.1684/ejd.2008.0487. Epub 2008 Aug 8.

Abstract

Pyoderma gangrenosum is a rare, painful, noninfectious, ulcerative, reactive neutrophilic skin condition. It is characterized by ulcers that can spread quickly showing undermined violaceous borders. Since there is no single diagnostic test, early diagnosis is always challenging. The aggressive nature of classical pyoderma gangrenosum may become apparent only with time. Pulmonary involvement of pyoderma gangrenosum maybe underreported. We describe a case of classical pyoderma gangrenosum in a 65-year-old man with pulmonary involvement, who presented with a painful fluctuate nodule and ulcer with mucopurulent and hemorrhagic exudates, and with a monoclonal gammopathy, IgA type. One month later the ulcer and hemoptysis all disappeared after treatment with glucocorticosteroids. The pulmonary manifestations of pyoderma gangrenosum were also reviewed.

摘要

坏疽性脓皮病是一种罕见、疼痛、非感染性、溃疡性、反应性嗜中性皮肤病。其特征为溃疡可迅速蔓延,呈现出潜行性紫褐色边缘。由于没有单一的诊断测试,早期诊断一直具有挑战性。经典坏疽性脓皮病的侵袭性可能只有随着时间推移才会显现出来。坏疽性脓皮病的肺部受累情况可能报告不足。我们描述了一例65岁男性患有肺部受累的经典坏疽性脓皮病病例,该患者表现为疼痛性波动结节及伴有黏液脓性和血性渗出物的溃疡,并伴有单克隆丙种球蛋白病,IgA 型。一个月后,经糖皮质激素治疗,溃疡和咯血均消失。同时对坏疽性脓皮病的肺部表现进行了综述。

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