Nava Arnulfo, Robles Gustavo, Mendoza Aguilar Carmen, Martínez-Ríos Marco A, Riebeling Carlos, Navarrete Susana, Reyes Pedro A
Unidad de Investigación en Epidemiología Clínica, UMAE del Hospital de Especialidades CMNO.
Rev Alerg Mex. 2007 Nov-Dec;54(6):201-4.
Measurement of antibodies to extracellular products of group A streptococcus, specifically streptolysin O (ASO), is useful to detect previous streptococcal infection, besides its ability to identify those asymptomatic carriers or to support diagnosis of poststreptococcal disease. An inflammatory process has been considered as a one variable that could be modifying the interpretation of ASO test.
identify in serum from clinically healthy subjects the covariability of antibodies to streptolysin O (ASO) serum concentration, high sensitivity C reactive protein (hsCRP).
87 serum samples from 87 clinically healthy subjects were tested. ASO, hsCRP, and total IgG were measured by nephelometry. Statistical analysis was performed using mean, median, and standard deviation with descriptive purpose; in addition, normality of the distribution of variables was determined. Spearman correlation test was performed in all cases. Significance was considered for p < or = 0.05.
A non-parametric distribution was exhibited by both ASO and hsCRP values. Gaussian distribution was finding only for IgG values. Spearman correlation values for ASO against both hsCRP and IgG were 0.19 (p = NS).
ASO values distribution did not correlate with dispersion of levels of hsCRP, neither IgG. This suggests that values obtained from clinically healthy subjects in this study where not modified influenced by a potential subjacent inflammatory process, neither IgG serum levels.
检测抗A组链球菌细胞外产物的抗体，特别是抗链球菌溶血素O（ASO），除了有助于识别无症状携带者或支持链球菌感染后疾病的诊断外，还有助于检测既往链球菌感染。炎症过程被认为是一个可能会改变ASO检测结果解读的变量。
确定临床健康受试者血清中抗链球菌溶血素O（ASO）血清浓度、高敏C反应蛋白（hsCRP）的协变性。
对87名临床健康受试者的87份血清样本进行检测。采用散射比浊法测定ASO、hsCRP和总IgG。使用均值、中位数和标准差进行描述性统计分析；此外，还确定了变量分布的正态性。所有病例均进行Spearman相关性检验。p≤0.05被认为具有统计学意义。
ASO和hsCRP值均呈非参数分布。仅IgG值呈高斯分布。ASO与hsCRP和IgG的Spearman相关值均为0.19（p=无统计学意义）。
ASO值分布与hsCRP水平的离散度以及IgG均无相关性。这表明，本研究中临床健康受试者获得的值未受到潜在的潜在炎症过程或IgG血清水平的影响而发生改变。
