抗链球菌溶血素O（ASO）滴度在尼日利亚拉各斯诊断链球菌感染中的意义逐渐减弱。

Waning significance of anti-streptolysin O (ASO) titres in diagnosing streptococcal infections in Lagos, Nigeria.

作者信息

Anyiwo C E, Obi C L, Nnaja N A

出版信息

East Afr Med J. 1989 Oct;66(10):636-40.

Abstract

A total of 200 serum specimens comprising 100 specimens from patients with streptococcal disease conditions, 50 from patients with other diseases and another 50 specimens from apparently healthy individuals were collected from Lagos University Teaching Hospital and from various areas of Lagos metropolis and screened for the presence of anti-streptolysin O (ASO). For streptococcal disease conditions, other diseases and for apparently healthy persons, anti-streptolysin O titres above 250 iu/ml recorded for each category of clinical conditions in terms of the number examined were 34%, 36% and 28% respectively. It is therefore suggested that high anti-streptolysin O (ASO) titres occur in apparently healthy individuals with no history of streptococcal infection and individuals with disease conditions other than those of streptococcal origin. Consequently the diagnosis of streptococcal diseases based on high titres of ASO in Lagos, is not pathognomonic, should be interpreted with caution and must not be definitive since healthy individuals and others without streptococcal infections develop high ASO titres.

摘要

从拉各斯大学教学医院以及拉各斯大都市的各个地区共收集了200份血清标本，其中包括100份来自链球菌疾病患者的标本、50份来自其他疾病患者的标本以及另外50份来自看似健康个体的标本，并对其进行抗链球菌溶血素O（ASO）检测。对于链球菌疾病患者、其他疾病患者以及看似健康的人，就每种临床情况所检测的数量而言，抗链球菌溶血素O滴度高于250 iu/ml的比例分别为34%、36%和28%。因此，建议在没有链球菌感染病史的看似健康个体以及患有非链球菌源性疾病的个体中会出现高抗链球菌溶血素O（ASO）滴度。因此，在拉各斯基于高滴度ASO诊断链球菌疾病并非具有特异性，应谨慎解读，且绝不能作为定论，因为健康个体和其他无链球菌感染的个体也会出现高ASO滴度。