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Design and synthesis of medium-ring lactam libraries inspired by octalactin a. A convergent-divergent approach.

作者信息

Brown Neil, Gao Ge, Minatoya Machiko, Xie Baohan, Vandervelde David, Lushington Gerald H, Perchellet Jean-Pierre H, Perchellet Elisabeth M, Crow Kyle R, Buszek Keith R

机构信息

Department of Chemistry, University of Missouri, 205 Spencer Chemical Laboratories, 5100 Rockhill Road, Kansas City, Missouri 64110, USA.

出版信息

J Comb Chem. 2008 Sep-Oct;10(5):628-31. doi: 10.1021/cc8001102. Epub 2008 Aug 12.

DOI:10.1021/cc8001102
PMID:18693764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2872934/
Abstract
摘要

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Curr Comput Aided Drug Des. 2008 Mar 1;4(1):23-34. doi: 10.2174/157340908783769292.
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Improved method for the diimide reduction of multiple bonds on solid-supported substrates.用于固体负载底物上多键二酰亚胺还原的改进方法。
J Org Chem. 2007 Apr 13;72(8):3125-8. doi: 10.1021/jo0622173. Epub 2007 Mar 17.
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Total synthesis of natural 8- and 9-membered lactones: recent advancements in medium-sized ring formation.天然八元及九元内酯的全合成：中环形成的最新进展
Chem Rev. 2007 Jan;107(1):239-73. doi: 10.1021/cr050045o.
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A systematic SAR study of C10 modified paclitaxel analogues using a combinatorial approach.使用组合方法对C10修饰的紫杉醇类似物进行系统的构效关系研究。
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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.药物研发环境中估算溶解度和渗透性的实验与计算方法。
Adv Drug Deliv Rev. 2001 Mar 1;46(1-3):3-26. doi: 10.1016/s0169-409x(00)00129-0.
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The synthesis of P-chiral amino acid-derived phosphonamidic anhydrides.
J Org Chem. 2000 Jul 28;65(15):4721-8. doi: 10.1021/jo000631b.
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Anticancer Res. 1998 Jan-Feb;18(1A):97-106.