Bhat L, Liu Y, Victory S F, Himes R H, Georg G I
Department of Medicinal Chemistry, Higuchi Bioscience Center, University of Kansas, Lawrence 66045, USA.
Bioorg Med Chem Lett. 1998 Nov 17;8(22):3181-6. doi: 10.1016/s0960-894x(98)00551-4.
A novel and efficient two-step, automated solution phase synthesis of a 26-membered combinatorial chemistry library of paclitaxel C7 esters was accomplished using the HP 7686 Solution Phase Synthesizer. Results of combinatorial synthesis, purification, analysis, and biological evaluation are described.
