Vanderveken M, Schepens M, Gerard Y
Department of General Surgery, General Hospital Middelheim, Antwerp, Belgium.
Int Surg. 1991 Apr-Jun;76(2):127-30.
The aim of this prospective study is to acquire clinical experience with a single high dose of tobramycin in prophylactic use. Sixty three patients undergoing elective colorectal surgery, were assigned to receive antibiotic prophylaxis (24 hours perioperatively) in the form of a single high dose of tobramycin and a classically recommended thrice-a-day (TID) administration of clindamycin. The planned dose for tobramycin was 3.3 mg/kg/day. Adjustment was made in case of impaired renal function. Serum levels of the drug were monitored. The results showed well predictable levels. Six out of fifty five evaluable patients (10.9%) presented postoperative infectious complications within the follow up period. No renal nor otovestibular toxicity was recorded.
这项前瞻性研究的目的是获取单次高剂量妥布霉素预防性使用的临床经验。63例接受择期结直肠手术的患者被分配接受抗生素预防（围手术期24小时），采用单次高剂量妥布霉素和经典推荐的每日三次（TID）克林霉素给药方式。妥布霉素的计划剂量为3.3mg/kg/天。肾功能受损时进行调整。监测药物的血清水平。结果显示水平具有良好的可预测性。55例可评估患者中有6例（10.9%）在随访期内出现术后感染并发症。未记录到肾毒性或耳前庭毒性。
