Schneider T L, Brubaker R F
Mayo Clinic, Rochester, Minnesota 55905.
Invest Ophthalmol Vis Sci. 1991 Aug;32(9):2507-10.
Epinephrine 2% drops were administered to one eye and a placebo to the fellow eye twice a day for 2 weeks in 18 normal human volunteers. The circadian rhythm of aqueous humor flow was measured by fluorophotometry. Epinephrine (compared with placebo) had no measurable effect on the rate of aqueous flow or the circadian rhythm of aqueous humor flow. These results suggest either that topical application of epinephrine cannot achieve a sustained effect on the mechanism of aqueous formation compared with endogenous epinephrine or that circulating epinephrine is not the sole or principal hormonal messenger that mediates the circadian rhythm of aqueous flow in humans. An experiment in which epinephrine was administered systemically might clarify this ambiguity.
在18名正常人类志愿者中，每天两次给一只眼睛滴入2%的肾上腺素滴眼液，另一只眼睛滴入安慰剂，持续2周。通过荧光光度法测量房水生成的昼夜节律。与安慰剂相比，肾上腺素对房水生成速率或房水生成的昼夜节律没有可测量的影响。这些结果表明，与内源性肾上腺素相比，局部应用肾上腺素可能无法对房水生成机制产生持续影响，或者循环中的肾上腺素不是介导人类房水生成昼夜节律的唯一或主要激素信使。一项全身性给予肾上腺素的实验可能会澄清这种模糊性。
