Raaberg L, Poulsen S S, Nexø E
Department B, University of Copenhagen, Denmark.
Histochemistry. 1991;95(5):471-5. doi: 10.1007/BF00315742.
Epidermal Growth Factor (EGF) in pharmacological doses is able to induce precoccious lung maturation in rabbits and sheeps. As EGF is probably acting in a para- or autocrine way, we have searched for EGF in the lungs. We report EGF immunoreactivity to be present in the type II pneumocytes of the rat from a couple of days prior to birth and throughout life. Further, we report EGF immunoreactivity to be present in cells in the bronchi and the bronchioles from day 20-21 of gestation and throughout life. G-200 gelchromatography of lung extracts indicates that the EGF-reactive material is a high molecular weight form of EGF. Since previous studies have shown that EGF in pharmacological doses is able to promote lung maturation, our results may imply a physiological role for EGF in the lungs.
药理剂量的表皮生长因子（EGF）能够诱导兔和羊的肺早熟成熟。由于EGF可能以旁分泌或自分泌方式起作用，我们在肺中寻找EGF。我们报告，从出生前几天到整个生命过程中，大鼠II型肺细胞中都存在EGF免疫反应性。此外，我们报告，从妊娠第20 - 21天到整个生命过程中，支气管和细支气管的细胞中都存在EGF免疫反应性。肺提取物的G - 200凝胶色谱表明，EGF反应性物质是一种高分子量形式的EGF。由于先前的研究表明药理剂量的EGF能够促进肺成熟，我们的结果可能意味着EGF在肺中具有生理作用。
