Mattisson Cecilia, Bogren Mats, Horstmann Vibeke, Tambs Kristian, Munk-Jörgensen Povl, Nettelbladt Per
Department of Clinical Sciences, University of Lund, Division of Psychiatry, The Lundby Study, Lund University Hospital, SE-221 85 Lund, Sweden.
J Affect Disord. 2009 Mar;113(3):203-15. doi: 10.1016/j.jad.2008.07.002. Epub 2008 Aug 9.
Depressive disorders are common and disabling. The Lundby Study is a prospective study of a community sample that started in 1947 (N=2550). In 1957, 1013 newcomers were added. The latest field investigation was carried out in 1997.
To identify risk factors for depressive disorders.
The Lundby database contains clinical assessments of the subjects made by psychiatrists. It also includes information about socio-demographic factors and episodes of somatic and mental disorders. Two different but partly overlapping cohorts from the same geographical area in 1947 (N=2470) and in 1957 (N=3310) were investigated. During follow-up 418 individuals experienced their first depressive disorder. For each cohort, possible risk factors were analysed by means of Cox regression analyses for the whole sample and for each sex separately.
The personality trait nervous/tense and anxiety disorders were statistically significant risk factors for depression for both genders. For males, the diagnoses alcohol disorders and tiredness disorder were risk factors. The personality trait subvalidity (low grade of energy) and nervous symptoms as a child were also risk factors for males. For females personality traits such as being easily hurt, abnormal/antisocial and tired/distracted were associated with depressive disorders.
Knowledge of risk factors may help to reduce incidence of depression.
抑郁症很常见且会导致残疾。隆德比研究是一项对始于1947年的社区样本进行的前瞻性研究（N = 2550）。1957年，新增了1013名新参与者。最近一次实地调查于1997年进行。
确定抑郁症的风险因素。
隆德比数据库包含精神科医生对受试者的临床评估。它还包括有关社会人口统计学因素以及躯体和精神障碍发作的信息。对来自同一地理区域的1947年（N = 2470）和1957年（N = 3310）的两个不同但部分重叠的队列进行了调查。在随访期间，418人经历了首次抑郁症发作。对于每个队列，通过Cox回归分析对整个样本以及分别对每个性别分析可能的风险因素。
性格特质紧张/焦虑和焦虑症是男女患抑郁症的统计学显著风险因素。对于男性，酒精障碍和疲劳障碍的诊断是风险因素。性格特质有效性不足（低能量水平）和儿童期神经症状也是男性的风险因素。对于女性，诸如易受伤害、异常/反社会和疲倦/分心等性格特质与抑郁症有关。
了解风险因素可能有助于降低抑郁症的发病率。
