Fogel J, Eaton W W, Ford D E
Department of Economics, Brooklyn College, City University of New York, Brooklyn, NY 11210, USA.
Acta Psychiatr Scand. 2006 Jan;113(1):36-43. doi: 10.1111/j.1600-0447.2005.00654.x.
To study the relationship of minor depression to first onset of major depressive disorder (MDD) among 1634 individuals over a 15-year follow-up using the Baltimore Epidemiologic Catchment Area cohort.
Logistic regression analyses were conducted with minor depression alone and also adjusting for anxiety, sociodemographic, and medical variables, with MDD as the outcome variable. Also, among those with minor depression, depressive symptom categories were studied with both logistic regression and population attributable risk (PAR) to determine if they predicted MDD.
Individuals with a history of minor depression had an odds ratio of more than 5 of having a first lifetime episode of MDD (adjusted OR: 5.37, 95% CI: 2.87, 10.06). Suicidal ideation, appetite/weight issues, and sleep difficulty had the highest PARs.
Minor depression strongly predicts MDD. Clinical and public health interventions for individuals with minor depression can potentially impact the pathway leading to MDD.
利用巴尔的摩流行病学集水区队列，对1634名个体进行为期15年的随访，研究轻度抑郁与重度抑郁症（MDD）首次发作之间的关系。
以MDD为结局变量，对单纯轻度抑郁以及同时调整焦虑、社会人口学和医学变量进行逻辑回归分析。此外，在患有轻度抑郁的人群中，采用逻辑回归和人群归因风险（PAR）研究抑郁症状类别，以确定它们是否能预测MDD。
有轻度抑郁病史的个体首次发生MDD终生发作的比值比超过5（调整后的OR：5.37，95%CI：2.87，10.06）。自杀意念、食欲/体重问题和睡眠困难的PAR最高。
轻度抑郁强烈预测MDD。针对轻度抑郁个体的临床和公共卫生干预可能会影响导致MDD的途径。
