Wakefield P E, James W D, Samlaska C P, Meltzer M S
Dermatology Service, Walter Reed Army Medical Center, Washington.
J Am Acad Dermatol. 1991 May;24(5 Pt 1):675-85. doi: 10.1016/0190-9622(91)70102-8.
Tumor necrosis factor is important in systemic and cutaneous defense, homeostasis, and many disease states. The numerous and diverse effects of tumor necrosis factor are best understood when considered as concentration-dependent, with normal homeostasis progressing to defense followed by toxic effects. Understanding tumor necrosis factor is important for the dermatologist as more studies appear in our literature and potential clinical uses of tumor necrosis factor (and possible anti-tumor necrosis factor agents) are realized.
肿瘤坏死因子在全身和皮肤防御、内环境稳定以及许多疾病状态中都很重要。当将肿瘤坏死因子的众多不同效应视为浓度依赖性时，最容易理解，即正常内环境稳定状态发展为防御状态，随后出现毒性效应。随着我们的文献中出现越来越多的研究，并且肿瘤坏死因子（以及可能的抗肿瘤坏死因子药物）的潜在临床应用得以实现，对于皮肤科医生来说，了解肿瘤坏死因子很重要。
