Guo Fang, Yuan Yuan
Liaoning Provincial Education Department, Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, and Key Laboratory of Cancer Etiology and Prevention (China Medical University), Shenyang City, Liaoning Province, People's Republic of China.
Department of Oncology, PLA Cancer Center, General Hospital of Northern Theater Command, Shenyang City, Liaoning Province, People's Republic of China.
Onco Targets Ther. 2020 Apr 20;13:3303-3318. doi: 10.2147/OTT.S241344. eCollection 2020.
Tumor necrosis factor (TNF) is the first cytokine used in tumor biotherapy, but TNF-related drugs are limited by the lack of specific targets. Tumor necrosis factor alpha-induced proteins (TNFAIPs), derived from TNF, is a protein family and participates in proliferation, invasion and metastasis of tumor cells. In order to better understand biological functions and potential roles of TNFAIPs in malignant tumors, this paper in the form of "Gene-Protein-Tumor correlation" summarizes the biological characteristics, physiological functions and mechanisms of TNFAIPs by searching National Center of Biotechnology Information, GeneCards, UniProt and STRING databases. The relationship between TNFAIPs and malignant tumors is analyzed, and protein-protein interaction diagram in members of TNFAIPs is drawn based on TNF for the first time. We find that TNF as a key factor is related to TNFAIP1, TNFAIP3, TNFAIP5, TNFAIP6, TNFAIP8 and TNFAIP9, which can be directly involved in activating TNFAIP1, TNFAIP5, TNFAIP8 and TNFAIP9. We confirm that the mechanism of TNFAIP1, TNFAIP2 and TNFAIP3 inducing tumors may be related to NF-κB signaling pathway, but the mechanism of tumor induction by other members of TNFAIPs is not clear. In the future, translational studies are needed to explore the mechanisms of TNF-TNFAIPs-tumors.
肿瘤坏死因子（TNF）是肿瘤生物治疗中首个应用的细胞因子，但TNF相关药物因缺乏特异性靶点而受到限制。肿瘤坏死因子α诱导蛋白（TNFAIPs）由TNF衍生而来，是一个蛋白家族，参与肿瘤细胞的增殖、侵袭和转移。为了更好地了解TNFAIPs在恶性肿瘤中的生物学功能和潜在作用，本文以“基因-蛋白-肿瘤相关性”的形式，通过检索美国国立生物技术信息中心、基因卡、通用蛋白质数据库和STRING数据库，总结了TNFAIPs的生物学特性、生理功能及机制。分析了TNFAIPs与恶性肿瘤的关系，并首次基于TNF绘制了TNFAIPs成员间的蛋白质-蛋白质相互作用图。我们发现，TNF作为关键因子与TNFAIP1、TNFAIP3、TNFAIP5、TNFAIP6、TNFAIP8和TNFAIP9相关，可直接参与激活TNFAIP1、TNFAIP5、TNFAIP8和TNFAIP9。我们证实，TNFAIP1、TNFAIP2和TNFAIP3诱导肿瘤的机制可能与NF-κB信号通路有关，但TNFAIPs其他成员诱导肿瘤的机制尚不清楚。未来，需要开展转化研究以探索TNF-TNFAIPs-肿瘤的机制。
