Ticholov K
Z Gesamte Inn Med. 1976 Sep 1;31(17):715-8.
It is reported on a patient with insulinoma whose diagnosis was made 16 years ago. Operation report: Insulinoma with the histological picture of a little expressed malignant degeneration. After 6 years recidivation of the clinical picture of an insulinoma. Operation report: Metastasis of a malignant insulinoma of the size of a hazel nut. After operation the patient had no complaints and was able to work for 8 years. Repeated hypoglycaemic conditions caused a third operation: In the cauda metastasis of a malignant insulinoma. After operation 18 months symptom-free with good health. The prognosis is discussed, emphasizing the unusually long course in malignant degeneration in the case described, as it hitherto was observed for the first time. It is also referred to some peculiarities of the carbohydrate metabolism of this patient. At length the necessity of an early diagnosis and a timely surgical treatment of the insulinoma is emphasized.
据报道，有一名胰岛素瘤患者，其诊断于16年前作出。手术报告：胰岛素瘤，组织学表现为轻度恶性变。6年后胰岛素瘤临床表现复发。手术报告：榛子大小的恶性胰岛素瘤转移。术后患者无不适，能够工作8年。反复出现低血糖情况导致第三次手术：恶性胰岛素瘤在胰尾转移。术后18个月无症状，健康状况良好。文中讨论了预后情况，强调了所描述病例中恶性变过程异常漫长，这是迄今为止首次观察到的情况。文中还提到了该患者碳水化合物代谢的一些特点。最后强调了胰岛素瘤早期诊断和及时手术治疗的必要性。
