Tikholov K
Vutr Boles. 1976;15(4):100-4.
A case of insulinoma is reported, with initial malignant degeneration, diagnosed and operated 16 years ago. Six years later hypoglycemic attacks appeared again and lymph metastasis from malignant degenerated insulinoma were found near to the pancreas. After a period of eight years, in good health state, a third surgical operation was performed because of repeated hypoglycemic attacks and a new metastasis from the insulinoma was found in the pancreas tail. The patient has no hypoglycemic phenomena 18 months after the last operation. Besides that long-period of progress of the malignant degenerated insulinoma, not observed so far, certain peculiarities of the carbohydrate metabolism of the patient are stressed upon, as well as the necessity of early diagnosis and timely surgical treatment of insulinoma.
报告一例胰岛素瘤病例，最初发生恶性变，于16年前确诊并接受手术。六年后低血糖发作再次出现，发现胰腺附近有恶性变胰岛素瘤的淋巴结转移。八年后，患者健康状况良好，但因反复低血糖发作而再次接受手术，发现胰岛素瘤在胰尾有新的转移灶。最后一次手术后18个月患者无低血糖现象。除了这种恶性变胰岛素瘤迄今未观察到的长期进展情况外，还强调了该患者碳水化合物代谢的某些特点，以及胰岛素瘤早期诊断和及时手术治疗的必要性。
