Coutinho Henrique D M, Costa José G M, Lima Edeltrudes O, Falcão-Silva Vivyanne S, Siqueira-Júnior José P
Laboratory of Research in Natural Products, Department of Physical and Biological Sciences, Center of Biological Sciences and Health, University of the Region of Cariri, Crato, Brazil.
Chemotherapy. 2008;54(4):328-30. doi: 10.1159/000151267. Epub 2008 Aug 12.
This is the first report testing the antibiotic resistance-modifying activity of Mentha arvensis.
In this study an ethanol extract of M. arvensis L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with conventional antibiotics against strains of Escherichia coli.
The growth of two E. coli strains tested was not inhibited by the extract. The minimum inhibitory concentration and minimal bactericide concentration values were >or=1 mg/ml for both strains of E. coli used. A potentiating effect of this extract on gentamicin was demonstrated. Similarly, there was a potentiating effect of chlorpromazine on kanamycin, amikacin and tobramycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides.
It is therefore suggested that extracts from M. arvensis could be used as a source of plant-derived natural products with resistance-modifying activity, such as in the case of gentamicin, constituting a new weapon against bacterial resistance to antibiotics, as with chlorpromazine.
这是首篇测试薄荷抗菌活性的报告。
本研究中，单独或与传统抗生素联合使用，测试了薄荷乙醇提取物和氯丙嗪对大肠杆菌菌株的抗菌活性。
测试的两种大肠杆菌菌株的生长未受提取物抑制。所使用的两种大肠杆菌菌株的最低抑菌浓度和最低杀菌浓度值均≥1mg/ml。证明该提取物对庆大霉素有增效作用。同样，氯丙嗪对卡那霉素、阿米卡星和妥布霉素也有增效作用，表明外排系统参与了对这些氨基糖苷类抗生素的耐药性。
因此，建议薄荷提取物可作为具有耐药性修饰活性的植物源天然产物的来源，如在庆大霉素的情况下，与氯丙嗪一样，构成对抗细菌抗生素耐药性的新武器。
