Laboratory of Research in Natural Products, Department of Biological Sciences, University of the Region of Cariri, Rua Cel. Antonio Luis 1161, Crato, CE, Brazil.
Biol Res Nurs. 2010 Apr;11(4):332-5. doi: 10.1177/1099800409340052. Epub 2009 Jul 24.
In this study, an ethanol extract of Turnera ulmifolia L. (EETU) and chlorpromazine (CPZ) were tested for their antimicrobial activity alone or in combination with conventional antibiotics against two strains of Escherichia coli (E. coli). The growth of neither E. coli strain was inhibited by the extract. The minimal inhibitory concentration (MIC) and minimal bactericidal concentration values were > or =1 mg/ml for both the strains of E. coli. However, the extract did increase the antimicrobial effects of amikacin, neomycin, and tobramycin. A similar effect of CPZ on amikacin, kanamycin, and tobramycin indicated the involvement of an efflux system in the resistance to these aminoglycosides. Results suggest that extracts from T. ulmifolia could be used as a plant-derived natural product with resistance-modifying activity, constituting a new weapon against bacterial resistance to antibiotics.
在这项研究中，番石榴叶乙醇提取物（EETU）和氯丙嗪（CPZ）被测试其单独或与常规抗生素联合对两种大肠杆菌（E. coli）菌株的抗菌活性。提取物既没有抑制大肠杆菌菌株的生长。最小抑菌浓度（MIC）和最小杀菌浓度值均> = 1 毫克/毫升，两种大肠杆菌菌株。然而，该提取物确实增加了阿米卡星、新霉素和妥布霉素的抗菌效果。CPZ 对阿米卡星、卡那霉素和妥布霉素的类似作用表明，一种外排系统参与了这些氨基糖苷类药物的耐药性。结果表明，番石榴叶提取物可作为具有耐药修饰活性的植物源性天然产物，成为对抗细菌对抗生素耐药性的新武器。
