Coutinho Henrique D M, Costa José G M, Lima Edeltrudes O, Falcão-Silva Vivyanne S, Siqueira-Júnior José P
Departamento de Ciências Biológicas, Centro de Ciências Biológicas e da Saúde, Universidade Regional do Cariri Crato, Crato (CE), Brazil.
Indian J Med Res. 2009 May;129(5):566-8.
The antibacterial and synergistic activity of the ethanol extract from Hyptis martiusii Benth. was assayed by microdillution. The growth of two isolates of Escherichia coli tested was inhibited by the extract. The minimum inhibitory and minimum bactericidal concentrations (MIC and MBC) values ranged from 512 and >1024 microg/ml for the E. coli 27 and 1024 and > 1024 microg/ml for the E. coli ATCC8539, respectively. A synergism between this extract and all aminoglycosides assayed was demonstrated. In the same form synergism between chlorpromazine and kanamycin, amikacin and tobramycin was observed, indicating the involvement of an efflux system. Extracts from H. martiusii could be used as a source of plant derived natural products with modifying antibiotic activity and these products may interact and affect multidrug resistance systems (MDR) as efflux pumps.
采用微量稀释法测定了皱叶香科科乙醇提取物的抗菌及协同活性。该提取物对所检测的两株大肠杆菌的生长均有抑制作用。大肠杆菌27的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）值分别为512和>1024μg/ml，大肠杆菌ATCC8539的MIC和MBC值分别为1024和>1024μg/ml。该提取物与所检测的所有氨基糖苷类药物之间均表现出协同作用。同样，还观察到氯丙嗪与卡那霉素、阿米卡星与妥布霉素之间存在协同作用，表明存在外排系统。皱叶香科科提取物可作为具有修饰抗生素活性的植物源天然产物的来源，这些产物可能会与多药耐药系统（MDR）如外排泵相互作用并产生影响。
