Sachdev P, Longragan C
Neuropsychiatric Institute, Prince Henry Hospital, Little Bay, Sydney, Australia.
J Nerv Ment Dis. 1991 Jul;179(7):381-91. doi: 10.1097/00005053-199107000-00001.
Akathisia is a common and distressing side effect of antipsychotic and some other psychotropic medications. This paper reviews the current state of knowledge of its clinical features, pathophysiology, and treatment. Restless legs syndrome and akathisia associated with Parkinson's disease are discussed in so far as they help understand drug-induced akathisia. The complexity of the disorder, and the difficulty in characterizing and quantifying it, may explain why researchers have relatively neglected akathisia for so long. The recent upsurge of research interest promises the hope of a better understanding of its pathophysiology so that effective therapy may result.
静坐不能是抗精神病药物和其他一些精神药物常见且令人痛苦的副作用。本文综述了其临床特征、病理生理学及治疗方面的现有知识。还讨论了与帕金森病相关的不宁腿综合征和静坐不能，因为它们有助于理解药物性静坐不能。该病症的复杂性以及对其进行特征描述和量化的困难，或许可以解释为什么研究人员长期以来相对忽视了静坐不能。最近研究兴趣的高涨有望带来更好地理解其病理生理学从而产生有效治疗方法的希望。
