Sachdev P
University of New South Wales, Prince Henry Hospital, Sydney, Australia.
Schizophr Res. 1995 Jul;16(1):33-45. doi: 10.1016/0920-9964(94)00058-g.
This paper traces the history of 'akathisia' and related syndromes, and examines the important studies that have helped shape our current understanding of the concept. Even though the term has come to be used synonymously with drug-induced akathisia, its origin was in the pre-neuroleptic era, and it is still often used to describe syndromes not related to medication. The literature clearly distinguishes restless legs syndrome (RLS) from akathisia. The complexity of the akathisia syndrome has increasingly become manifest, and a number of sub-types have been described. Recent attempts have been made to operationalize its diagnostic criteria and understand its pathophysiology. Akathisia due to non-neuroleptic drugs, in particular the serotonin-specific reuptake inhibitors (SSRIs), has also received much attention. The development of newer psychopharmacotherapeutic drugs, with different side-effects profiles, has made this focus pertinent and timely.
本文追溯了“静坐不能”及相关综合征的历史，并审视了有助于形成我们当前对该概念理解的重要研究。尽管该术语已开始与药物性静坐不能同义使用，但其起源于抗精神病药物出现之前的时代，并且仍常被用于描述与药物无关的综合征。文献明确区分了不安腿综合征（RLS）与静坐不能。静坐不能综合征的复杂性日益显现，已描述了多种亚型。最近有人尝试将其诊断标准操作化并了解其病理生理学。非抗精神病药物所致的静坐不能，尤其是5-羟色胺特异性再摄取抑制剂（SSRI）引起的静坐不能，也受到了很多关注。具有不同副作用特征的新型精神药物治疗药物的开发，使得这一关注点既相关又及时。
