Frommann Ingo, Brinkmeyer Jürgen, Ruhrmann Stephan, Hack Eva, Brockhaus-Dumke Anke, Bechdolf Andreas, Wölwer Wolfgang, Klosterkötter Joachim, Maier Wolfgang, Wagner Michael
Department of Psychiatry and Psychotherapy, Rheinische Friedrich-Wilhelms University of Bonn, Bonn, Germany.
Int J Psychophysiol. 2008 Dec;70(3):192-205. doi: 10.1016/j.ijpsycho.2008.07.003. Epub 2008 Jul 22.
Alterations of the auditory evoked P300 potential are among the most reliable biological markers of schizophrenia. The aim of this study was to assess the amplitude, latency, and topography of the P300 in individuals at clinical high risk for psychosis.
P300 event-related potentials were acquired with an auditory oddball paradigm from 100 patients putatively in an early initial prodromal state (EIPS) for psychosis or in a late initial prodromal state (LIPS), according to the criteria of the German Research Network on Schizophrenia, and from 40 healthy controls comparable with respect to age, gender, and estimated verbal IQ.
In the LIPS group, P300 amplitude was significantly smaller at midline and left hemispheric electrodes in comparison with controls. In the EIPS group, P300 amplitude was significantly reduced at a left temporoparietal site (TP7). A family history of schizophrenia was associated with smaller posterior P300 amplitudes in high-risk individuals. Midline P300 amplitudes were smaller in LIPS who had experienced already brief limited intermittent psychotic symptoms.
Smaller P300 amplitudes are present prior to a putative onset of psychosis in high-risk individuals. Selective left temporoparietal amplitude deficits may indicate a trait-like abnormality whereas deficits at sagittal midline electrodes may be partly determined by the changes that underlie the appearance of psychotic symptoms. P300 amplitude may be associated with left superior temporal lobe maturation abnormalities followed by further functional impairments later in life. Our follow-up study will reveal whether P300 amplitude alterations predict psychosis and help to targeting early intervention.
听觉诱发电位P300的改变是精神分裂症最可靠的生物学标志物之一。本研究旨在评估精神病临床高危个体中P300的波幅、潜伏期和地形图。
根据德国精神分裂症研究网络的标准，采用听觉oddball范式，对100名可能处于精神病早期初始前驱状态（EIPS）或晚期初始前驱状态（LIPS）的患者以及40名年龄、性别和估计言语智商匹配的健康对照者进行P300事件相关电位检测。
与对照组相比，LIPS组在中线和左侧半球电极处的P300波幅明显较小。在EIPS组中，左侧颞顶叶部位（TP7）的P300波幅显著降低。精神分裂症家族史与高危个体较小的后部P300波幅相关。在已经经历过短暂有限间歇性精神病症状的LIPS个体中，中线P300波幅较小。
高危个体在假定的精神病发作之前就存在较小的P300波幅。选择性的左侧颞顶叶波幅缺陷可能表明一种特质样异常，而矢状中线电极处的缺陷可能部分由精神病症状出现所依据的变化决定。P300波幅可能与左侧颞上叶成熟异常有关，随后在生命后期出现进一步的功能损害。我们的随访研究将揭示P300波幅改变是否能预测精神病，并有助于确定早期干预目标。
