Tozzoli R, Barzilai O, Ram M, Villalta D, Bizzaro N, Sherer Y, Shoenfeld Y
Laboratory of Clinical Biochemistry, Civic Hospital, Latisana, Italy.
Autoimmun Rev. 2008 Dec;8(2):112-5. doi: 10.1016/j.autrev.2008.07.013.
Different types of infection are implicated in the pathogenesis of autoimmune thyroid diseases (AITD) through molecular mimicry or other mechanisms, but their role is disputed. Human studies support direct or indirect evidence of involvement of some viral and bacterial agents, but reports have provided conflicting and inconclusive results. Using a new automated multiplex array platform for the detection of antibodies, we determined seroreactivity against Toxoplasma gondii, Treponema pallidum, rubella virus, cytomegalovirus, and Epstein-Barr virus in a large group of Italian AITD patients and healthy controls. Only IgG concentrations against T. gondii were significantly higher in AITD patients than in controls, suggesting that these protozoa may be involved in the initiation of both Hashimoto's thyroiditis and Graves' disease.
不同类型的感染通过分子模拟或其他机制参与自身免疫性甲状腺疾病（AITD）的发病机制，但其作用存在争议。人体研究支持某些病毒和细菌病原体参与其中的直接或间接证据，但报告结果相互矛盾且尚无定论。我们使用一种新型自动化多重检测阵列平台来检测抗体，在一大群意大利AITD患者和健康对照中测定了针对弓形虫、梅毒螺旋体、风疹病毒、巨细胞病毒和EB病毒的血清反应性。AITD患者中仅针对弓形虫的IgG浓度显著高于对照组，这表明这些原生动物可能参与了桥本甲状腺炎和格雷夫斯病的发病起始过程。
