Birkent Hakan, Karacalioglu Ozgur, Merati Albert L, Akcam Timur, Gerek Mustafa
Department of Otolaryngology-Head and Neck Surgery, Gulhane Military Medical Academy, Ankara, Turkey.
Ann Otol Rhinol Laryngol. 2008 Jul;117(7):523-7. doi: 10.1177/000348940811700710.
Hypothyroidism has long been considered to have an impact on phonation. In this study, objective evaluation of vocal function in women with hypothyroidism was performed in order to characterize potential dysphonia; their subsequent response to thyroid hormone replacement was prospectively studied. It was hypothesized that thyroid hormone replacement therapy in this cohort would have an objectively measurable impact on vocal function.
Prospectiv evaluation of objective voice parameters and concurrent determination of serum thyroid status was executed both before and after thyroid hormone replacement in a cohort of patients who had had total thyroidectomy. Objective voice parameters before and after treatment were compared.
Twenty-four female subjects were recruited over an 18-month period. After surgery, all subjects were hypothyroid (mean thyroid-stimulating hormone level, 81.38 mIU/L; range, 25.26 to 100.00 mIU/L) before replacement. After hormone therapy, their mean thyroid-stimulating hormone level dropped to 1.20 mIU/L (range, 0.28 to 3.83 mIU/L). The mean fundamental frequency significantly increased from a pretreatment average of 223.48 +/- 36.10 Hz to 237.64 +/- 38.81 Hz. Other measured voice parameters (jitter, shimmer, amplitude perturbation quotient, pitch perturbation quotient, noise-to-harmonics ratio, and maximum phonation time) were not affected.
Thyroid hormone replacement therapy following total thyroidectomy has a measurable impact on mean fundamental frequency in female patients. The mechanism of this effect is not known.
长期以来，甲状腺功能减退症一直被认为会对发声产生影响。在本研究中，对甲状腺功能减退症女性患者的发声功能进行了客观评估，以确定潜在的发音困难特征；并对她们随后接受甲状腺激素替代治疗的反应进行了前瞻性研究。研究假设是，该队列中的甲状腺激素替代疗法将对发声功能产生客观可测量的影响。
对一组接受全甲状腺切除术的患者在甲状腺激素替代治疗前后进行客观嗓音参数的前瞻性评估，并同时测定血清甲状腺状态。比较治疗前后的客观嗓音参数。
在18个月的时间里招募了24名女性受试者。术后，所有受试者在接受替代治疗前均为甲状腺功能减退（促甲状腺激素平均水平为81.38 mIU/L；范围为25.26至100.00 mIU/L）。激素治疗后，她们的促甲状腺激素平均水平降至1.20 mIU/L（范围为0.28至3.83 mIU/L）。平均基频从治疗前的平均223.48±36.10 Hz显著增加到237.64±38.81 Hz。其他测量的嗓音参数（抖动、闪烁、幅度微扰商、音高微扰商、噪声与谐波比和最长发声时间）未受影响。
全甲状腺切除术后的甲状腺激素替代疗法对女性患者的平均基频有可测量的影响。这种效应的机制尚不清楚。
