Junuzović-Žunić Lejla, Ibrahimagić Amela, Altumbabić Selma
Department of Speech and Language Pathology and Audiology, School of Education and Rehabilitation, University of Tuzla, Tuzla, Bosnia and Herzegovina.
Department of Audiology and Phoniatrics, Tuzla University Clinical Center, Tuzla, Bosnia and Herzegovina.
Eurasian J Med. 2019 Jun;51(2):101-105. doi: 10.5152/eurasianjmed.2018.18331.
This study investigated acoustic and perceptual characteristics of the voice of patients with thyroid gland disorders such as hypothyroidism and hyperthyroidism immediately after the diagnosis was made and six months later, after using drug therapy.
The study includes 20 female outpatients with hypothyroidism and 27 female outpatients with hyperthyroidism. The criterion for the selection of the patients was a thyroid gland disorder medical diagnosis, no history of voice disorders and absence of other possible causes of voice changes. Acoustic, perceptual and aerodynamic parameters were assessed. Acoustic analysis was performed by specific software. Experienced speech and language pathologists made perceptual voice assessment by using grade, roughness, breathiness, asthenia, and strain (GRBAS) scale.
Significant differences in patients with hypothyroidism were established on parameter amplitude perturbation, jitter and noise-to-harmonics ratio between pretreatment and posttreatment period, in which patients took drug therapy. In group of patients with hyperthyroidism significant difference was noted only on aerodynamic parameter maximum phonation time. There were a significant differences in all perceptual parameters in both groups of patients (p<0.05) in pre and posttreatment, except on grade and asthenia parameter in the group of patients with hypothyroidism and parameter grade was borderline insignificant in the group of patients with hyperthyroidism.
Voice quality is affected by thyroid disease. Thyroid gland disorders cause minor changes in acoustic voice parameters of patients with hypothyroidism and hyperthyroidism, but perceptual deviations in these patients are especially noticeable.
本研究调查了甲状腺功能减退症和甲状腺功能亢进症等甲状腺疾病患者在确诊后及药物治疗六个月后的嗓音声学和感知特征。
该研究纳入了20名甲状腺功能减退症女性门诊患者和27名甲状腺功能亢进症女性门诊患者。患者入选标准为甲状腺疾病医学诊断、无嗓音疾病史且无其他可能导致嗓音变化的原因。评估了声学、感知和空气动力学参数。声学分析通过特定软件进行。经验丰富的言语和语言病理学家使用等级、粗糙度、气息声、无力和紧张（GRBAS）量表进行嗓音感知评估。
甲状腺功能减退症患者在治疗前和治疗后（接受药物治疗）期间，在参数幅度微扰、抖动和噪声与谐波比方面存在显著差异。在甲状腺功能亢进症患者组中，仅在空气动力学参数最大发声时间上有显著差异。两组患者在治疗前和治疗后所有感知参数均存在显著差异（p<0.05），甲状腺功能减退症患者组的等级和无力参数除外，甲状腺功能亢进症患者组的等级参数接近无显著差异。
嗓音质量受甲状腺疾病影响。甲状腺疾病会导致甲状腺功能减退症和甲状腺功能亢进症患者的嗓音声学参数发生微小变化，但这些患者的感知偏差尤为明显。
