Stogowska Ewa, Kamiński Karol Adam, Ziółko Bartosz, Kowalska Irina
Department of Internal Medicine and Metabolic Diseases, Medical University of Bialystok, Bialystok, Poland.
Department of Population Medicine and Civilization Diseases Prevention, Medical University of Bialystok, Bialystok, Poland.
Endocr Connect. 2022 Mar 15;11(3):e210505. doi: 10.1530/EC-21-0505.
The subject of vocal changes accompanying pathological conditions, although still not well explored, seems to be promising. The discovery of laryngeal receptors for sex hormones and thyroid hormones can strongly support the hypothesis of changes in voice due to various endocrinopathies. On the other hand, the impairment of the proper function of the vocal apparatus can also be caused in the process of the microvasculature complications of diabetes mellitus. This review was a comprehensive summary of the accessible literature concerning the influence of selected endocrinopathies on subjective and objective voice parameters. We analysed a total number of 16 English-language research papers from the PubMed database, released between 2008 and 2021, describing vocal changes in reproductive disorders such as polycystic ovary syndrome and congenital adrenal hyperplasia, thyroid disorders in shape of hypo- or hyperthyroidism and type 2 diabetes mellitus. The vast majority of the analysed articles proved some changes in voice in all mentioned conditions, although the detailed affected vocal parameters frequently differed between research. We assume that the main cause of the observed conflicting results might stem from non-homogeneous methodology designs of the analysed studies.
尽管伴随病理状况的嗓音变化这一主题仍未得到充分研究，但似乎很有前景。性激素和甲状腺激素喉受体的发现有力地支持了因各种内分泌疾病导致嗓音变化的假说。另一方面，糖尿病微血管并发症过程中也可能导致发声器官正常功能受损。本综述全面总结了关于所选内分泌疾病对主观和客观嗓音参数影响的现有文献。我们从PubMed数据库中分析了2008年至2021年间发表的16篇英文研究论文，这些论文描述了多囊卵巢综合征和先天性肾上腺增生等生殖系统疾病、甲状腺功能减退或亢进以及2型糖尿病等甲状腺疾病中的嗓音变化。绝大多数分析文章都证明在所有上述情况下嗓音存在一些变化，尽管不同研究中受影响的具体嗓音参数常常有所不同。我们认为观察到结果相互矛盾的主要原因可能源于所分析研究的方法设计不一致。
