组蛋白H3变体的组织特异性表达及翻译后修饰
Tissue-specific expression and post-translational modification of histone H3 variants.
作者信息
Garcia Benjamin A, Thomas C Eric, Kelleher Neil L, Mizzen Craig A
机构信息
Institute for Genomic Biology, Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
出版信息
J Proteome Res. 2008 Oct;7(10):4225-36. doi: 10.1021/pr800044q. Epub 2008 Aug 14.
Abstract
Analyses of histone H3 from 10 rat tissues using a Middle Down proteomics platform revealed tissue-specific differences in their expression and global PTM abundance. ESI/FTMS with electron capture dissociation showed that, in general, these proteins were hypomodified in heart, liver and testes. H3.3 was hypermodified compared to H3.2 in some, but not all tissues. In addition, a novel rat testes-specific H3 protein was identified with this approach.
摘要
使用中向下蛋白质组学平台对来自10种大鼠组织的组蛋白H3进行分析，结果显示其表达和整体翻译后修饰丰度存在组织特异性差异。带有电子捕获解离的电喷雾傅里叶变换质谱表明，总体而言，这些蛋白质在心脏、肝脏和睾丸中修饰不足。在一些而非所有组织中，与H3.2相比，H3.3的修饰程度更高。此外，用这种方法鉴定出一种新的大鼠睾丸特异性H3蛋白。
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