Coffelt Seth B, Scandurro Aline B
Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, USA.
Cancer Res. 2008 Aug 15;68(16):6482-5. doi: 10.1158/0008-5472.CAN-08-0044.
Recent evidence suggests that inflammatory molecules play critical roles in the development and progression of numerous tumors. However, one specific group of inflammatory molecules whose importance has been established in host immune responses, termed alarmins, has been largely overlooked in cancer biology. The function of several alarmins-including the defensins, LL-37, and HMGB1-in tumor development, progression, or suppression is discussed here. Taken together, these studies indicate that alarmins represent potential new targets for manipulation in a variety of tumors.
最近的证据表明，炎症分子在众多肿瘤的发生和发展过程中发挥着关键作用。然而，一类在宿主免疫反应中已被证实其重要性的特定炎症分子——警报素，在癌症生物学中却基本上被忽视了。本文讨论了几种警报素（包括防御素、LL-37和高迁移率族蛋白B1）在肿瘤发生、发展或抑制中的作用。综合来看，这些研究表明警报素是多种肿瘤潜在的新治疗靶点。
