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药物性鼻炎:半导体激光下鼻甲消融术对鼻塞及减充血剂滥用的治疗效果

Rhinitis medicamentosa: therapeutic effect of diode laser inferior turbinate reduction on nasal obstruction and decongestant abuse.

作者信息

Caffier Philipp P, Frieler Katja, Scherer Hans, Sedlmaier Benedikt, Göktas Onder

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery; Charité-University Medicine Berlin, Berlin, Germany.

出版信息

Am J Rhinol. 2008 Jul-Aug;22(4):433-9. doi: 10.2500/ajr.2008.22.3199.

Abstract

BACKGROUND

The purpose of this study was to evaluate long-term outcomes of an outpatient-based diode laser inferior turbinate reduction (ITR) in therapy-refractory rhinitis medicamentosa (RM).

METHODS

In a prospective clinical investigation, 42 consecutive RM patients underwent videoendoscopic ITR with a diode laser after topical anesthetic preparation. Intra- and perioperative details were recorded including the occurrence of bleeding, crusting, pain, or discomfort. Treatment efficiency was assessed by follow-ups 1 and 6 weeks as well as 6 and 12 months after surgery. Subjective pre- and posttherapeutic nasal airflow (NA) and patient satisfaction were rated on visual analog scales (VASs). Assessment of the long-term objective clinical effectiveness was based on rhinomanometry, IT photodocumentation, and the recurrent need for decongestants.

RESULTS

Preoperative addiction to decongestants lasted 5 +/- 2 years (mean +/- SD). There was no major bleeding requiring nasal packing, and there were no other perioperative complications. Postoperative edema disappeared within the 1st week and crusting within 6 weeks after surgery. VAS was characterized by very low values for intraoperative pain and discomfort and high postoperative patient satisfaction. After 6 months, NA data revealed a significant improvement of subjective VAS and objective rhinomanometry (250.4-413.9 cm3/s inspiration at 150 Pa). A total of 88% of patients managed to successfully stop decongestant abuse after 6 months (74% after 1 year).

CONCLUSION

In therapy-refractory RM, outpatient diode laser ITR of hyperplastic IT represents a highly effective, safe, and well-tolerated treatment option that provides long-lasting recovery by markedly improving NA and stopping addiction to nasal decongestants.

摘要

背景

本研究旨在评估门诊二极管激光下鼻甲缩小术(ITR)治疗难治性药物性鼻炎(RM)的长期疗效。

方法

在一项前瞻性临床研究中,42例连续性RM患者在局部麻醉准备后接受了二极管激光视频内镜下ITR。记录术中和围手术期细节,包括出血、结痂、疼痛或不适的发生情况。在术后1周和6周以及6个月和12个月进行随访,评估治疗效果。通过视觉模拟量表(VAS)对治疗前后的主观鼻气流(NA)和患者满意度进行评分。基于鼻阻力测量、IT照片记录以及对减充血剂的反复需求来评估长期客观临床疗效。

结果

术前对减充血剂的依赖持续5±2年(均值±标准差)。未发生需要鼻腔填塞的大出血,也没有其他围手术期并发症。术后水肿在第1周内消失,结痂在术后6周内消失。VAS显示术中疼痛和不适程度很低,术后患者满意度很高。6个月后,NA数据显示主观VAS和客观鼻阻力测量有显著改善(在150 Pa时吸气量从250.4 cm³/s提高到413.9 cm³/s)。6个月后,共有88%的患者成功停止滥用减充血剂(1年后为74%)。

结论

在难治性RM中,门诊二极管激光增生性ITR是一种高效、安全且耐受性良好的治疗选择,通过显著改善NA和停止对鼻腔减充血剂的依赖实现持久康复。

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