Caffier Philipp P, Frieler Katja, Scherer Hans, Sedlmaier Benedikt, Göktas Onder
Department of Otorhinolaryngology, Head and Neck Surgery; Charité-University Medicine Berlin, Berlin, Germany.
Am J Rhinol. 2008 Jul-Aug;22(4):433-9. doi: 10.2500/ajr.2008.22.3199.
The purpose of this study was to evaluate long-term outcomes of an outpatient-based diode laser inferior turbinate reduction (ITR) in therapy-refractory rhinitis medicamentosa (RM).
In a prospective clinical investigation, 42 consecutive RM patients underwent videoendoscopic ITR with a diode laser after topical anesthetic preparation. Intra- and perioperative details were recorded including the occurrence of bleeding, crusting, pain, or discomfort. Treatment efficiency was assessed by follow-ups 1 and 6 weeks as well as 6 and 12 months after surgery. Subjective pre- and posttherapeutic nasal airflow (NA) and patient satisfaction were rated on visual analog scales (VASs). Assessment of the long-term objective clinical effectiveness was based on rhinomanometry, IT photodocumentation, and the recurrent need for decongestants.
Preoperative addiction to decongestants lasted 5 +/- 2 years (mean +/- SD). There was no major bleeding requiring nasal packing, and there were no other perioperative complications. Postoperative edema disappeared within the 1st week and crusting within 6 weeks after surgery. VAS was characterized by very low values for intraoperative pain and discomfort and high postoperative patient satisfaction. After 6 months, NA data revealed a significant improvement of subjective VAS and objective rhinomanometry (250.4-413.9 cm3/s inspiration at 150 Pa). A total of 88% of patients managed to successfully stop decongestant abuse after 6 months (74% after 1 year).
In therapy-refractory RM, outpatient diode laser ITR of hyperplastic IT represents a highly effective, safe, and well-tolerated treatment option that provides long-lasting recovery by markedly improving NA and stopping addiction to nasal decongestants.
本研究旨在评估门诊二极管激光下鼻甲缩小术(ITR)治疗难治性药物性鼻炎(RM)的长期疗效。
在一项前瞻性临床研究中,42例连续性RM患者在局部麻醉准备后接受了二极管激光视频内镜下ITR。记录术中和围手术期细节,包括出血、结痂、疼痛或不适的发生情况。在术后1周和6周以及6个月和12个月进行随访,评估治疗效果。通过视觉模拟量表(VAS)对治疗前后的主观鼻气流(NA)和患者满意度进行评分。基于鼻阻力测量、IT照片记录以及对减充血剂的反复需求来评估长期客观临床疗效。
术前对减充血剂的依赖持续5±2年(均值±标准差)。未发生需要鼻腔填塞的大出血,也没有其他围手术期并发症。术后水肿在第1周内消失,结痂在术后6周内消失。VAS显示术中疼痛和不适程度很低,术后患者满意度很高。6个月后,NA数据显示主观VAS和客观鼻阻力测量有显著改善(在150 Pa时吸气量从250.4 cm³/s提高到413.9 cm³/s)。6个月后,共有88%的患者成功停止滥用减充血剂(1年后为74%)。
在难治性RM中,门诊二极管激光增生性ITR是一种高效、安全且耐受性良好的治疗选择,通过显著改善NA和停止对鼻腔减充血剂的依赖实现持久康复。