Larsen Alf Inge, Skadberg Øyvind, Aarsland Torbjørn, Kvaløy Jan Terje, Lindal Sigurd, Omland Torbjørn, Dickstein Kenneth
Department of Cardiology, Stavanger University Hospital, Norway.
Int J Cardiol. 2009 Aug 21;136(3):358-62. doi: 10.1016/j.ijcard.2008.04.085. Epub 2008 Aug 15.
This study examined the potential association between skeletal muscle histological findings and circulating levels of N-terminal Atrial natriuretic peptide (NT-proANP) and N-terminal B-type natriuretic peptide (NT-proBNP) at rest and during exercise in patients with moderate chronic heart failure. We report a significant correlation between muscle fibre roundness, defined as ratio of fibre perimeter squared to fibre area, and plasma levels of N-BNP. This finding suggests that the degree of intrafibrillar edema is related to the secretion of NT-proBNP.
本研究检测了中度慢性心力衰竭患者静息和运动时骨骼肌组织学检查结果与N末端心房利钠肽（NT-proANP）及N末端B型利钠肽（NT-proBNP）循环水平之间的潜在关联。我们报告称，肌纤维圆度（定义为纤维周长平方与纤维面积之比）与N-BNP血浆水平之间存在显著相关性。这一发现表明，肌原纤维内水肿程度与NT-proBNP的分泌有关。
