Gjertsson Peter, Ekberg Sofia, Lomsky Milan, Gan Li-Ming, Edenbrandt Lars
Department of Clinical Physiology, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Int J Cardiol. 2009 Aug 14;136(2):171-7. doi: 10.1016/j.ijcard.2008.04.082. Epub 2008 Aug 13.
Left ventricular (LV) volumes and ejection fraction (LVEF) are assessed using ECG-gated myocardial perfusion scintigraphy (MPS) and echocardiography. We have developed CAFU, a new automated method for the quantification of MPS images. AutoEF software is a new automated method for quantifying echocardiograms (Tomtec research arena). The aim of the study was to compare these new methods with standard methods.
Patients undergoing clinical MPS were invited to an echocardiographic examination. Eighty-eight patients were included, mean age 64+/-10 years, 50% men. LV volumes and LVEF from the echocardiographic examinations were calculated using the AutoEF software and calculations according to Simpson's rule. The LV volumes and LVEF from the MPS images were calculated using CAFU, Quantitative gated-SPECT (QGS) and Emory Cardiac Toolbox (ECT).
The MPS methods revealed larger LV volumes and LVEF compared with the echocardiographic methods. CAFU showed an excellent correlation with QGS and ECT (0.91-0.99). The correlations between the MPS and the echocardiographic methods (0.47-0.88), as well as between the AutoEF-assessed values and Simpson's method (0.57-0.87), were lower, however statistically significant. The correlations between the methods were higher for LV volumes than for LVEF.
There was better agreement between LV volumes and LVEF values from the three MPS methods than between those from the two echocardiographic methods. The echocardiographic methods produced significantly lower LV volumes and LVEF compared with the MPS methods. In the clinical situation, LV volumes and LVEF values from different types of examination or different software packages should be treated with caution.
使用心电图门控心肌灌注显像（MPS）和超声心动图评估左心室（LV）容积和射血分数（LVEF）。我们开发了CAFU，一种用于定量MPS图像的新自动化方法。AutoEF软件是一种用于定量超声心动图的新自动化方法（Tomtec研究领域）。本研究的目的是将这些新方法与标准方法进行比较。
邀请接受临床MPS检查的患者进行超声心动图检查。纳入88例患者，平均年龄64±10岁，50%为男性。使用AutoEF软件并根据辛普森法则计算超声心动图检查的LV容积和LVEF。使用CAFU、定量门控单光子发射计算机断层扫描（QGS）和埃默里心脏工具箱（ECT）计算MPS图像的LV容积和LVEF。
与超声心动图方法相比，MPS方法显示出更大的LV容积和LVEF。CAFU与QGS和ECT显示出极好的相关性（0.91 - 0.99）。然而，MPS与超声心动图方法之间的相关性（0.47 - 0.88）以及AutoEF评估值与辛普森方法之间的相关性（0.57 - 0.87）较低，但具有统计学意义。各方法之间LV容积的相关性高于LVEF。
三种MPS方法得出的LV容积和LVEF值之间的一致性优于两种超声心动图方法。与MPS方法相比，超声心动图方法得出的LV容积和LVEF显著更低。在临床情况下，应谨慎对待来自不同类型检查或不同软件包的LV容积和LVEF值。
