Akalın Erdal Nihat, Yaylalı Olga, Kıraç Fatma Suna, Yüksel Doğangün, Kılıç Mustafa
Denizli State Hospital, Department of Nuclear Medicine, Denizli, Turkey.
Mol Imaging Radionucl Ther. 2012 Aug;21(2):69-74. doi: 10.4274/Mirt.359. Epub 2012 Aug 1.
We aimed to evaluate the role of gated myocardial perfusion SPECT (MPS) and to investigate whether only the invasive coronary angiography (CAG) is sufficient in the diagnosis of the coronary artery disease (CAD) in women.
Sixty-four women (62±10 years) with known CAD were included in this study. They had echocardiography (ECHO), stress/rest gated MPS and invasive CAG. Coronary stenosis as of > 50 % in invasive CAG was accepted as significant. Gated MPS data were compared with invasive CAG and ECHO.
Invasive CAG results were abnormal in 34 patients, and normal in 30 cases. Myocardial ischemia was detected by gated MPS in 22/ 30 cases with normal invasive CAG, 6 had mild coronary stenosis in major coronary arteries ranging from 30% to 50% in invasive CAG. 16/ 22 women were diagnosed as metabolic syndrome according to MetSend Diagnostic Criteria and only 8 of 30 patients with normal invasive CAG had false positive MPS data on the reevaluation by a nuclear cardiologist.
We think that invasive coronary angiography method is not sufficient alone in the diagnosis of CAD in women. Gated MPS study is recommended to achieve the final decision for myocardial ischemia in the cases with CAD and raw data must always be evaluated to avoid attenuation artifacts.
None declared.
我们旨在评估门控心肌灌注单光子发射计算机断层扫描（MPS）的作用，并研究仅通过有创冠状动脉造影（CAG）在女性冠状动脉疾病（CAD）诊断中是否足够。
本研究纳入了64名已知患有CAD的女性（62±10岁）。她们接受了超声心动图（ECHO）、负荷/静息门控MPS和有创CAG检查。有创CAG中冠状动脉狭窄>50%被视为显著狭窄。将门控MPS数据与有创CAG和ECHO进行比较。
有创CAG结果在34例患者中异常，30例正常。在有创CAG正常的30例患者中，门控MPS检测到22例心肌缺血，其中6例在主要冠状动脉中有轻度冠状动脉狭窄，有创CAG显示狭窄范围为30%至50%。根据代谢综合征诊断标准，16/22名女性被诊断为代谢综合征，在有创CAG正常的30例患者中，只有8例在核心脏病专家重新评估时MPS数据出现假阳性。
我们认为仅靠有创冠状动脉造影方法在女性CAD诊断中是不够的。对于CAD患者，建议进行门控MPS研究以做出关于心肌缺血的最终决定，并且必须始终评估原始数据以避免衰减伪影。
未声明。
