Ertesvåg Ase, Naderi Soheil, Blomhoff Heidi Kiil
Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, PO Box 1112, Blindern, N-0317 Oslo, Norway.
Semin Immunol. 2009 Feb;21(1):36-41. doi: 10.1016/j.smim.2008.06.005. Epub 2008 Aug 13.
Vitamin A protects against development of infectious diseases, and B cells are important players in this process. Keys to the protective role of retinoic acid (RA) against infections appear to be its ability to enhance antibody responses against T-cell dependent and independent type 2 antigens, as well as to locally stimulate IgA production in mucosal tissues. The elucidation of molecular mechanisms involved in RA-mediated regulation of proliferation and differentiation of B cells not only helps us to understand how RA differentially regulates subsets of B cells, but might also lead to more targeted treatment of selected immune disorders and B cell malignancies.
维生素A可预防传染病的发生，而B细胞在这一过程中发挥着重要作用。视黄酸（RA）抗感染保护作用的关键似乎在于其能够增强针对T细胞依赖性和非依赖性2型抗原的抗体反应，以及在粘膜组织中局部刺激IgA的产生。阐明RA介导的B细胞增殖和分化调控的分子机制，不仅有助于我们理解RA如何差异调节B细胞亚群，还可能导致对特定免疫疾病和B细胞恶性肿瘤进行更有针对性的治疗。
