Department of Population Health Sciences, University of Wisconsin-Madison, WI.
Alzheimer Dis Assoc Disord. 2014 Jan-Mar;28(1):44-9. doi: 10.1097/WAD.0b013e3182949f06.
Arterial stiffness may be associated with cognitive function. In this study, pulse wave velocity (PWV) was measured from the carotid to femoral (CF-PWV) and from the carotid to radial (CR-PWV) with the Complior SP System. Cognitive function was measured by 6 tests of executive function, psychomotor speed, memory, and language fluency. A total of 1433 participants were included (mean age 75 y, 43% men). Adjusting for age, sex, education, pulse rate, hemoglobin A1C, high-density lipoprotein cholesterol, hypertension, cardiovascular disease history, smoking, drinking, and depression symptoms, a CF-PWV>12 m/s was associated with a lower Mini-Mental State Examination score (coefficient: -0.31, SE: 0.11, P=0.005), fewer words recalled on Auditory Verbal Learning Test (coefficient: -1.10, SE: 0.43, P=0.01), and lower score on the composite cognition score (coefficient: -0.10, SE: 0.05, P=0.04) and marginally significantly associated with longer time to complete Trail Making Test-part B (coefficient: 6.30, SE: 3.41, P=0.06), CF-PWV was not associated with Trail Making Test-part A, Digit Symbol Substation Test, or Verbal Fluency Test. No associations were found between CR-PWV and cognitive performance measures. Higher large artery stiffness was associated with worse cognitive function, and longitudinal studies are needed to confirm these associations.
动脉僵硬度可能与认知功能有关。在这项研究中，使用 Complior SP 系统测量了从颈动脉到股动脉（CF-PWV）和从颈动脉到桡动脉（CR-PWV）的脉搏波速度（PWV）。认知功能通过 6 项执行功能、运动速度、记忆和语言流畅性测试进行测量。共纳入 1433 名参与者（平均年龄 75 岁，43%为男性）。在校正年龄、性别、教育程度、脉搏率、糖化血红蛋白、高密度脂蛋白胆固醇、高血压、心血管疾病史、吸烟、饮酒和抑郁症状后，CF-PWV>12 m/s 与简易精神状态检查评分较低（系数：-0.31，SE：0.11，P=0.005）、听觉词语学习测验中回忆的单词较少（系数：-1.10，SE：0.43，P=0.01）以及复合认知评分较低（系数：-0.10，SE：0.05，P=0.04）有关，与 Trail Making Test-part B 完成时间较长（系数：6.30，SE：3.41，P=0.06）也有边缘显著关联，CF-PWV 与 Trail Making Test-part A、数字符号替代测验或言语流畅性测验无关。CR-PWV 与认知表现测量之间没有关联。大动脉僵硬度越高，认知功能越差，需要进行纵向研究来证实这些关联。
