Hua Qi, Tan Jing, Liu Dong-xia, Wen Jing, Xing Xiu-rong
Department of Cardiology, Xuan Wu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2005 Dec;33(12):1088-91.
To analyze the changes of carotid-femoral and carotid-radial pulse wave velocity in patients with essential hypertension, and effects of age and levels blood pressure levels on these changes.
Automatic pulse wave velocity (PWV) measuring system was applied to examine carotid-femoral PWV (CFPWV) and carotid-radial PWV (CRPWV) as the parameters reflecting central elastic large arterial and peripheral muscular medium-sized arterial elasticity respectively. 517 hypertensive patients aged 17-82 years (272 males and 245 females, mean age 52.0 +/- 13.0 years) and 118 healthy subjects aged 19-82 years (52 males and 66 females, mean age 54.2 +/- 13.8 years) were recruited in the study.
CFPWV increased with age in both groups (P < 0.001), whereas CRPWV did not change significantly. CFPWV and CRPWV both increased with blood pressure. A stepwise multiple regression analysis demonstrated that age and systolic blood pressure were positively related to CFPWV independently, while diastolic blood pressure was significantly associated with CRPWV.
Age and components of blood pressure exert different effects on elasticity of central elastic large artery and peripheral muscular medium-sized artery. Examining the change of large arterial elasticity has important clinical value in hypertensive patients.
分析原发性高血压患者颈股动脉和颈桡动脉脉搏波速度的变化，以及年龄和血压水平对这些变化的影响。
应用自动脉搏波速度（PWV）测量系统检测颈股动脉脉搏波速度（CFPWV）和颈桡动脉脉搏波速度（CRPWV），分别作为反映中心弹性大动脉和外周肌性中动脉弹性的参数。本研究纳入了517例年龄在17 - 82岁的高血压患者（男性272例，女性245例，平均年龄52.0±13.0岁）和118例年龄在19 - 82岁的健康受试者（男性52例，女性66例，平均年龄54.2±13.8岁）。
两组患者的CFPWV均随年龄增加而升高（P < 0.001），而CRPWV无明显变化。CFPWV和CRPWV均随血压升高而增加。逐步多元回归分析表明，年龄和收缩压分别与CFPWV呈正相关，而舒张压与CRPWV显著相关。
年龄和血压成分对中心弹性大动脉和外周肌性中动脉弹性的影响不同。检测大动脉弹性变化在高血压患者中具有重要的临床价值。
