Lasisi Akeem O
Department of Otorhinolaryngology, Faculty of Clinical Sciences, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Eur Arch Otorhinolaryngol. 2009 May;266(5):647-52. doi: 10.1007/s00405-008-0794-6. Epub 2008 Aug 14.
Vitamin A deficiency is still a serious public health problem affecting an estimated 127 million preschool children. The resulting immunological dysfunctions lead to increased risks of respiratory tract infections, diarrhoeal diseases and blindness, among others. The aim of this study is to determine the significance of the role of serum retinol in the etiology of acute suppurative otitis media (ASOM) and its chronicity (CSOM). In a prospective follow-up of patients with ASOM for 6-9 months, serum retinol determination was done using the high performance liquid chromatography. Participants comprised 358 ASOM and 52 control subjects. Six-month follow-up was achieved in 264 subjects (74%); of these, there was persistence of otorrhoea (CSOM) in 116, while 148 had resolved ASOM. Of the 264 subjects, 146 were males and 118 were females, between the ages of 6 months and 9 years and a mean of 7 years (SD = 2.32), whereas the control subjects comprised 29 males and 22 females, between the ages of 6 months and 11 years and a mean of 7.8 years (SD = 3.6). The range of serum retinol in the ASOM subjects was 1.63-2.64 microg/L, mean of 1.53 microg/L, median value of 2.61 microg/L and (SD = 0.16). Among control subjects, the range was 2.5-2.8 microg/L, mean of 2.58 microg/L and median value of 2.61 microg/L (SD = 0.14) (Table 1). The range of serum retinol in the resolved ASOM subjects was 1.61-2.63 microg/L, mean of 2.07 microg/L and median value of 2.09 microg/L (SD = 0.16) while the CSOM subjects ranged between 0.8-2.86 microg/L, mean of 1.58 microg/L and median value of 1.28 microg/L, (SD = 0.48) (Table 2). Univariate analysis using unpaired t test to compare the mean serum retinol revealed significant difference between ASOM and control (P = 0.0000) and between resolved ASOM and CSOM (P = 0.0000). In conclusion, hyporetinolaemia was a significant etiological factor in the etiology ASOM and CSOM, suggesting retinol supplementation as one strategy in control of SOM.
维生素A缺乏仍然是一个严重的公共卫生问题，估计影响着1.27亿学龄前儿童。由此产生的免疫功能障碍会增加呼吸道感染、腹泻病和失明等疾病的风险。本研究的目的是确定血清视黄醇在急性化脓性中耳炎（ASOM）及其慢性化（CSOM）病因中的作用意义。在对ASOM患者进行6至9个月的前瞻性随访中，使用高效液相色谱法测定血清视黄醇。参与者包括358名ASOM患者和52名对照受试者。264名受试者（74%）完成了6个月的随访；其中，116人持续性耳漏（CSOM），148人ASOM已痊愈。在这264名受试者中，146名是男性，118名是女性，年龄在6个月至9岁之间，平均年龄为7岁（标准差 = 2.32），而对照受试者包括29名男性和22名女性，年龄在6个月至11岁之间，平均年龄为7.8岁（标准差 = 3.6）。ASOM受试者的血清视黄醇范围为1.63 - 2.64微克/升，平均为1.53微克/升，中位数为2.61微克/升，（标准差 = 0.16）。在对照受试者中，范围为2.5 - 2.8微克/升，平均为2.58微克/升，中位数为2.61微克/升（标准差 = 0.14）（表1）。已痊愈的ASOM受试者的血清视黄醇范围为1.61 - 2.63微克/升，平均为2.07微克/升，中位数为2.09微克/升（标准差 = 0.16），而CSOM受试者的范围为0.8 - 2.86微克/升，平均为1.58微克/升，中位数为1.28微克/升，（标准差 = 0.
