Aydogan Filiz, Aydin Emine, Tastan Eren, Arslan Necmi, Senes Mehmet, Unlu Ilhan, Kavuzlu Ali
Department of Otorhinolaryngology, Ministry of Health Ankara Training and Research Hospital, Konutkent Mah. Oyak 1 Blok 20/9 Çayyolu, Ankara, Turkey.
Department of Otorhinolaryngology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey.
Indian J Otolaryngol Head Neck Surg. 2013 Dec;65(Suppl 3):594-7. doi: 10.1007/s12070-012-0564-z. Epub 2012 Aug 21.
The aim of this study is to determine whether the serum levels of vitamin A, vitamin E, copper and zinc have a role in the development of otitis media with effusion (OME) in childhood. This prospective study was conducted between February 2010 and February 2011 at a tertiary Otorhinolaryngoloy Clinic. There were 113 subjects and subdivided into three groups. Group 1 consisted of 44 patients who underwent adenoidectomy with ventilation tube placement due to OME. Group 2 consisted of 43 patients underwent adenoidectomy alone and group 3,called control group, included 26 healthy children. Serum values of vitamin A, vitamin E, copper and zinc were measured preoperatively. Comparison of the patient groups showed that group 1 patients had significantly lower serum zinc levels than group 2 patients (p = 0.002), although differences between both patients groups and controls were not significant. We found that the differences among the three groups in terms of serum levels of vitamin A, vitamin E and copper were not statistically significant (p > 0.05). The results of this study showed that serum levels of vitamin A, vitamin E and copper may not play a role on development of OME. We postulated that high serum zinc status may have the preventive effect in the predisposition to OME which may related to adenoid hyperplasia.
本研究的目的是确定血清维生素A、维生素E、铜和锌水平在儿童分泌性中耳炎（OME）的发病过程中是否起作用。这项前瞻性研究于2010年2月至2011年2月在一家三级耳鼻喉科诊所进行。共有113名受试者，分为三组。第一组由44例因OME接受腺样体切除术并放置通气管的患者组成。第二组由43例仅接受腺样体切除术的患者组成，第三组为对照组，包括26名健康儿童。术前测量血清维生素A、维生素E、铜和锌值。患者组之间的比较表明，第一组患者的血清锌水平显著低于第二组患者（p = 0.002），尽管两组患者与对照组之间的差异不显著。我们发现三组之间血清维生素A、维生素E和铜水平的差异无统计学意义（p > 0.05）。本研究结果表明，血清维生素A、维生素E和铜水平可能对OME的发病不起作用。我们推测，高血清锌状态可能对与腺样体增生相关的OME易感性具有预防作用。
