Hartmann Marc, Mattern Eline S K, Huisman Jennifer, van Houwelingen Gert K, de Man Frits H A F, Stoel Martin G, Danse Peter W, Louwerenburg Hans W, von Birgelen Clemens
Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Haaksbergerstraat 55, Enschede, 7513ER, The Netherlands.
Int J Cardiovasc Imaging. 2009 Jan;25(1):13-23. doi: 10.1007/s10554-008-9338-9. Epub 2008 Aug 13.
Intravascular ultrasound radiofrequency (RF-IVUS) data permit the analysis of coronary plaque composition in vivo and is used as an endpoint of ongoing pharmacological intervention trials. We assessed the reproducibility of volumetric RF-IVUS analyses in mild-to-moderately diseased atherosclerotic human coronary arteries in vivo. A total of 9,212 IVUS analyses on cross-sectional IVUS frames was performed to evaluate the reproducibility of volumetric RF-IVUS measurements in 33 coronary segments with a length of 27 +/- 7 mm. For vessel, lumen, and plaque + media volume the relative measurement differences (P = NS for all) were (A = intraobserver comparison, same pullback) -0.40 +/- 1.0%; -0.48 +/- 1.4%; -0.35 +/- 1.6%, (B = intraobserver comparison, repeated pullback) -0.42 +/- 1.2%; -0.52 +/- 1.8%; -0.43 +/- 4.5% (C = interobserver comparison, same pullback) 0.71 +/- 1.8%; 0.71 +/- 2.2%, and 0.89 +/- 5.0%, respectively. For fibrous, fibro-lipidic, calcium, and necrotic-core volumes the relative measurement differences (P = NS for all) were (A) 0.45 +/- 2.1%; -1.12 +/- 4.9%; -0.84 +/- 2.1%; -0.22 +/- 1.8%, (B) 1.40 +/- 4.1%; 1.26 +/- 6.7%; 2.66 +/- 7.4%; 0.85 +/- 4.4%, and (C) -1.60 +/- 4.9%; 3.85 +/- 8.2%; 1.66 +/- 7.5%, and -1.58 +/- 4.7%, respectively. Of note, necrotic-core volume showed on average the lowest measurement variability. Thus, in mild-to-moderate atherosclerotic coronary artery disease the reproducibility of volumetric compositional RF-IVUS measurements from the same pullback is relatively high, but lower than the reproducibility of geometrical IVUS measurements. Measurements from repeated pullbacks and by different observers show acceptable reproducibilities; the volumetric measurement of the necrotic-core shows on average the highest reproducibility of the compositional RF-IVUS measurements.
血管内超声射频（RF-IVUS）数据允许在体内分析冠状动脉斑块成分，并用作正在进行的药物干预试验的终点。我们评估了在体内轻度至中度病变的人类动脉粥样硬化冠状动脉中进行容积性RF-IVUS分析的可重复性。对横截面IVUS图像进行了总共9212次IVUS分析，以评估在33个长度为27±7mm的冠状动脉节段中容积性RF-IVUS测量的可重复性。对于血管、管腔以及斑块+中膜体积，相对测量差异（所有P值均无统计学意义）分别为（A = 同一观察者比较，同一次回撤）-0.40±1.0%；-0.48±1.4%；-0.35±1.6%，（B = 同一观察者比较，重复回撤）-0.42±1.2%；-0.52±1.8%；-0.43±4.5%，（C = 不同观察者比较，同一次回撤）0.71±1.8%；0.71±2.2%，以及0.89±5.0%。对于纤维、纤维脂质、钙化和坏死核心体积，相对测量差异（所有P值均无统计学意义）分别为（A）0.45±2.1%；-1.12±4.9%；-0.84±2.1%；-0.22±1.8%，（B）1.40±4.1%；1.26±6.7%；2.66±7.4%；0.85±4.4%，以及（C）-1.60±4.9%；3.85±8.2%；1.66±7.5%，以及-1.58±4.7%。值得注意的是，坏死核心体积平均显示出最低的测量变异性。因此，在轻度至中度动脉粥样硬化性冠状动脉疾病中，同一次回撤的容积性成分RF-IVUS测量的可重复性相对较高，但低于几何IVUS测量的可重复性。不同观察者重复回撤测量显示出可接受的可重复性；坏死核心的容积测量平均显示出成分RF-IVUS测量中最高的可重复性。
