Sinúes B, Nuñez E, Bernal M L, Alcala A, Saenz M A, Conde B
Department of Pharmacology, Medical School, University of Zaragoza, Spain.
Mutat Res. 1991 Aug;260(4):337-42. doi: 10.1016/0165-1218(91)90019-i.
In order to perform biological monitoring of exposure to radiation and contrast media, we evaluated the micronucleus count (MN) and the mitotic index (MI) in peripheral blood lymphocytes from patients undergoing excretory urography with diatrizoate (20 patients) and ioxaglate (20 patients). Three samples were taken for each patient: A (before exploration), B (immediately after exploration) and C (7 days later). There were no significant differences in the radiation doses received, nor in the dose of contrast agent, between both groups. The micronucleus count increased significantly in sample B in both groups, the increase being more statistically significant in the diatrizoate group (p less than 0.01) than in the ioxaglate group (p less than 0.05). One week later, the MN were still slightly high (p less than 0.05) in the diatrizoate group only. These results suggest a clastogenic effect which depends, to a great extent, on the nature of the contrast medium.
为了对辐射和造影剂暴露进行生物监测，我们评估了接受泛影葡胺（20例患者）和碘克沙醇（20例患者）排泄性尿路造影的患者外周血淋巴细胞中的微核计数（MN）和有丝分裂指数（MI）。每位患者采集三个样本：A（检查前）、B（检查后即刻）和C（7天后）。两组患者接受的辐射剂量以及造影剂剂量均无显著差异。两组样本B中的微核计数均显著增加，泛影葡胺组的增加在统计学上比碘克沙醇组更显著（p<0.01 vs p<0.05）。一周后，仅泛影葡胺组的微核计数仍略高（p<0.05）。这些结果表明存在一种致断裂效应，在很大程度上取决于造影剂的性质。
