Nuñez M E, Sinués B
Department of Pharmacology and Radiology, Medical School, University of Zaragoza, Spain.
Invest Radiol. 1990 Jun;25(6):692-7. doi: 10.1097/00004424-199006000-00013.
Possible cytogenic alterations due to radiologic contrast medium in patients undergoing a common radiologic examination is studied. Two groups of 20 patients each were used. Group I consisted of patients undergoing excretory urography, using sodium and meglumine diatrizoate as contrast. A different agent, sodium and meglumine ioxaglate, was used with group II. Three blood samples were taken from each patient before urography, immediately after urography, and 1 week later. The frequency of sister chromatid exchanges (SCE) and chromosomal aberrations (CA) were found to increase significantly in the B samples from both groups, that of group I being higher (P less than .01 compared with P less than .05). Furthermore, these alterations were found to persist in the C samples from group I. No modification of the Proliferating Rate Index (PRI) was found. The osmolarity or other components of the contrast media studied could be involved in the process. The results indicate that ioxaglate produces less cytogenic damage than diatrizoate.
研究了接受普通放射检查的患者因放射造影剂可能出现的细胞遗传学改变。使用了两组，每组20名患者。第一组由接受排泄性尿路造影的患者组成，使用泛影酸钠和泛影葡胺作为造影剂。第二组使用了另一种造影剂，碘克沙醇钠和碘克沙醇葡胺。在尿路造影前、造影后即刻以及1周后，从每位患者采集三份血样。发现两组的B样本中姐妹染色单体交换（SCE）和染色体畸变（CA）的频率均显著增加，第一组更高（与P小于0.05相比，P小于0.01）。此外，发现第一组C样本中的这些改变持续存在。未发现增殖率指数（PRI）有变化。所研究的造影剂的渗透压或其他成分可能参与了这一过程。结果表明，碘克沙醇产生的细胞遗传学损伤比泛影酸盐少。
