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美国普通人群中奥施康定与其他镇痛类阿片药物非医疗用途的相关因素。

Correlates of extramedical use of OxyContin versus other analgesic opioids among the US general population.

作者信息

Martins Silvia S, Storr Carla L, Zhu Hong, Chilcoat Howard D

机构信息

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, 8th Floor, Baltimore, MD 21205-1900, United States.

出版信息

Drug Alcohol Depend. 2009 Jan 1;99(1-3):58-67. doi: 10.1016/j.drugalcdep.2008.06.013. Epub 2008 Aug 15.

Abstract

BACKGROUND

There has been substantial public and media attention regarding extramedical use of OxyContin, but few studies focus on the characteristics of extramedical OxyContin users and whether they differ from extramedical other opioid users.

METHODS

We used data from 8218 respondents who were past-year extramedical opioid analgesic users in the 2005 and 2006 National Survey of Drug Use and Health (NSDUH). We investigated differences in socio-demographic and psychiatric characteristics associated with past-year extramedical OxyContin use (n=1144) versus extramedical other opioid analgesics use (n=7074). Data on opioid sources was compared among past-month users. We also compared extramedical opioid users (n=8218) versus other drug users (n=16,214), and individuals with an analgesic disorder who had past-year extramedical OxyContin use (n=339) versus those with other opioid use (n=820).

RESULTS

Past-year opioid users were more likely than users of other illegal drugs to be more educated and have a past-year major depressive episode. Past-year OxyContin users were more likely than other opioid users to be 18-25 years old (aOR=1.9[1.1,3.2]), and have mental health and deviant behavior problems. Those with past-year analgesic disorder who used OxyContin were more likely to be younger, sell illegal drugs (aOR=2.5[1.5,4.2]), and use illegal drugs than those who used other opioids. Past-month OxyContin users were more likely than past-month other opioid users to buy analgesics from drug dealers/other strangers and obtain opioid analgesics from multiple sources.

CONCLUSION

Our findings point out differences between OxyContin and other opioid users that might help prevention specialists and assist efforts to curb opioid analgesics diversion.

摘要

背景

羟考酮的非医疗用途已受到公众和媒体的大量关注,但很少有研究关注非医疗用途的羟考酮使用者的特征,以及他们与非医疗用途的其他阿片类药物使用者是否存在差异。

方法

我们使用了2005年和2006年全国药物使用和健康调查(NSDUH)中8218名过去一年有非医疗用途阿片类镇痛药使用史的受访者的数据。我们调查了过去一年非医疗用途使用羟考酮(n = 1144)与非医疗用途使用其他阿片类镇痛药(n = 7074)相关的社会人口统计学和精神特征差异。比较了过去一个月使用者中阿片类药物来源的数据。我们还比较了非医疗用途阿片类药物使用者(n = 8218)与其他药物使用者(n = 16214),以及过去一年有非医疗用途羟考酮使用史的镇痛障碍患者(n = 339)与有其他阿片类药物使用史的患者(n = 820)。

结果

过去一年使用阿片类药物的人比使用其他非法药物的人更有可能受过更高教育且在过去一年有重度抑郁发作。过去一年使用羟考酮的人比其他阿片类药物使用者更有可能年龄在18 - 25岁(调整后比值比[aOR]=1.9[1.1, 3.2]),且有心理健康和越轨行为问题。过去一年有镇痛障碍且使用羟考酮的人比使用其他阿片类药物的人更有可能年龄较小、贩卖非法药物(aOR = 2.5[1.5, 4.2])以及使用非法药物。过去一个月使用羟考酮的人比过去一个月使用其他阿片类药物的人更有可能从毒贩/其他陌生人处购买镇痛药,并从多个来源获取阿片类镇痛药。

结论

我们的研究结果指出了羟考酮使用者与其他阿片类药物使用者之间的差异,这可能有助于预防专家并协助遏制阿片类镇痛药的转移。

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