Lee Laurie A
Pediatric Allergy and Immunology, Duke University Medical Center, Box 3559, Durham, NC 27710, USA.
Food Chem Toxicol. 2008 Oct;46 Suppl 10:S6-S11. doi: 10.1016/j.fct.2008.07.019. Epub 2008 Jul 30.
Atopic dermatitis (AD) is the most common chronic skin disease in children. The defective barrier function of the skin in patients with AD allows foreign proteins to enter the body and interact with components of the innate and adaptive immune systems. The immune response characteristic of AD is complex with the majority of patients making IgE in response to ingested and/or inhaled antigens. Although IgE-mediated mechanisms may represent initial immune responses, they are only one element of a biphasic inflammatory response. Identifying the role of specific allergens in a patient's skin disease is critical yet difficult because diagnostic tests are often not able to distinguish asymptomatic sensitization from true clinical allergy.
特应性皮炎（AD）是儿童中最常见的慢性皮肤病。AD患者皮肤的屏障功能缺陷使得外来蛋白质能够进入体内，并与先天性和适应性免疫系统的成分相互作用。AD的免疫反应特征复杂，大多数患者会针对摄入和/或吸入的抗原产生IgE。虽然IgE介导的机制可能代表初始免疫反应，但它们只是双相炎症反应的一个要素。确定特定过敏原在患者皮肤病中的作用至关重要但却困难，因为诊断测试往往无法区分无症状致敏与真正的临床过敏。
