Hansson V, Djoseland O, Torgersen O, Ritzen E M, French F S, Nayfeh S N
Andrologia. 1976;8(3):195-202. doi: 10.1111/j.1439-0272.1976.tb02135.x.
Studies over the last few years have greatly increased our knowledge about target cells for sex hormones and gonadotropins in the testis. A diagram illustrating our present state of knowledge is given in Fig. 1. LH is the principle stimulus of testosterone secretion by the Leydig cells. Direct effects of estrogens and androgens on these cells might modulate the response to LH. Androgens are apparently influencing the differentiation and the contractility of peritubular cells. FSH is the principle stimulus for Sertoli cell secretory function before puberty, although androgens are acting synergistically with FSH. After puberty, androgens alone are capable of maintaining on optimal secretory function of the Sertoli cells. In addition to normal secretory activity of the Sertoli cells, direct stimulation of the germ cells by androgens is needed in order maintain spermatogenesis.
过去几年的研究极大地增加了我们对睾丸中性激素和促性腺激素靶细胞的了解。图1给出了一个说明我们目前知识状况的示意图。LH是睾丸间质细胞分泌睾酮的主要刺激因素。雌激素和雄激素对这些细胞的直接作用可能会调节对LH的反应。雄激素显然会影响睾丸周细胞的分化和收缩性。在青春期前，FSH是支持细胞分泌功能的主要刺激因素，不过雄激素与FSH起协同作用。青春期后，仅雄激素就能维持支持细胞的最佳分泌功能。除了支持细胞的正常分泌活动外，为了维持精子发生，雄激素还需要直接刺激生殖细胞。
