Jiang Yin, Li Shiping, Xu Wenming, Ying Junjie, Qu Yi, Jiang Xiaohui, Zhang Ayuan, Yue Yan, Zhou Ruixi, Ruan Tiechao, Li Jinhui, Mu Dezhi
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.
Front Endocrinol (Lausanne). 2022 Mar 2;13:818272. doi: 10.3389/fendo.2022.818272. eCollection 2022.
Brain and muscle aryl-hydrocarbon receptor nuclear translocator like protein1 (), a core component of circadian oscillation, is involved in many physiological activities. Increasing evidence has demonstrated the essential role of in reproductive physiology. For instance, -knockout (KO) mice were infertile, with impaired reproductive organs and gametes. Additionally, in -KO mice, hormone secretion and signaling of hypothalamus-pituitary-gonadal (H-P-G) hormones were also disrupted, indicating that H-P-G axis was impaired in -KO mice. Moreover, both -KO mice and BMAL1-knockdown by small interfering RNA (siRNA) cultured steroidogenic cells showed that was associated with gonadal steroidogenesis and expression of related genes. Importantly, also participates in pathogenesis of human reproductive diseases. In this review, we elaborate on the impaired reproduction of BMAL1-KO mice including the reproductive organs, reproductive endocrine hormones, and reproductive processes, highlighting the vital role of in fertility and reproductive endocrinology.
脑和肌肉芳烃受体核转运体样蛋白1（BMAL1）是昼夜节律振荡的核心组成部分，参与许多生理活动。越来越多的证据表明BMAL1在生殖生理学中具有重要作用。例如，BMAL1基因敲除（KO）小鼠不育，生殖器官和配子受损。此外，在BMAL1-KO小鼠中，下丘脑-垂体-性腺（H-P-G）激素的分泌和信号传导也受到干扰，表明BMAL1-KO小鼠的H-P-G轴受损。此外，BMAL1-KO小鼠和通过小干扰RNA（siRNA）敲低BMAL1的培养类固醇生成细胞均表明，BMAL1与性腺类固醇生成及相关基因的表达有关。重要的是，BMAL1还参与人类生殖疾病的发病机制。在本综述中，我们阐述了BMAL1-KO小鼠生殖功能受损的情况，包括生殖器官、生殖内分泌激素和生殖过程，强调了BMAL1在生育能力和生殖内分泌学中的重要作用。
